Recombinant Human ADAMTS5, His-tagged ADAMTS5-534H

Recombinant Human ADAMTS5, His-tagged

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Recombinant Human ADAMTS5, His-tagged

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Cat. No. : ADAMTS5-534H
Product Overview : Recombinant Human ADAMTS5 was expressed in abaculovirussystem and purified from insect cells. The enzyme contains the catalytic domain, the disintegrin domain and the thrombospondin type-1 motif of full-length ADAMTS-5 followed by a C-terminal His tag, 50 kDa.
Description : Aggrecanases belong to a family of ADAMTS proteases (ADAMTS = A disintegrin and metalloprotease with thrombospondin motifs). ADAMTS enzymes are comprised of an N-terminal prodomain, a catalytic domain, a disintegrin domain, one or more thrombospondin (TS) motifs, a cysteine-rich domain and a spacer domain of variable length. The prodomains are cleaved off intracellularly and the enzymes are processed further from their C-terminal ends after secretion. Aggrecanases are responsible for aggrecan degradation in osteoarthritic joints. ADAMTS-5 was found to be the principal aggrecanase in mouse cartilage.
Source : Baculovirus.
Activity : Activity (mU/mg) is specified on the vial.
Purity : ≥ 50%.
Unit Definition : One milliunit of protease hydrolyzes 1 nanomole of aggrecan interglobular domain substrate per minute at pH 7.5 at 37°C.
Formulation : 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 50 mM Imidazol, 0.05% Brij-35.
Application : Used as a positive control in FRET-based and aggrecan enzyme activity assays, Western blot, IP, and ELISA.
Storage : Store at -80°C. Avoid multiple thaw-freeze cycles.
Gene Name : ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 [ Homo sapiens ]
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAMTS11; FLJ36738; ADAMTS5; a disintegrin and metalloproteinase with thrombospondin motifs 5; ADAM-TS5; ADAM-TS 5; ADAMTS-11;ADAM-TS 11; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); EC 3.4.24.-
Gene ID : 11096
mRNA Refseq : NM_007038
Protein Refseq : NP_008969
MIM : 605007
Chromosome Location : 21q21.3
Function : integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding

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