Active Recombinant Human Insulin-like Growth Factor 2 (Somatomedin A)

• Cat.No.: IGF2-373H
• Product Overview: Recombinant human Xeno-free pro-IGF-II is expressed inhuman 293 cellsas a monomeric glycoprotein with an apparent molecular mass of 25 kDa.

Specification

• Cat. No.: IGF2-373H
• Description: Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Glycosylation contributes to stability in cell growth media and other applications. IGF-II expressed in E. coli is typically 7.5 kDa and nonglycosylated.
• Source: Human 293 cells.
• Activity: 2 to 8 ng/mL ED50.
• Purity: >95%.
• Endotoxin: Endotoxin-free.
• Purity Confirmation: The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
• Activity Assay: The specific activity was determined by the dose-dependent stimulation of the proliferation of MCF-7 cells (human breast cancer cell line).
• Pathways: Diabetes pathways

Gene Information

• Gene Name: IGF2 insulin-like growth factor 2 (somatomedin A) [ Homo sapiens ]
• Synonyms: insulin-like growth factor 2 (somatomedin A);INSIGF; pp9974; C11orf43; FLJ22066; FLJ44734; IGF2; insulin-like growth factor 2; IGF-II; somatomedin A; somatomedin-A; insulin-like growth factor II;insulin-like growth factor type 2; putative insulin-like growth factor II associated protein;chromosome 11 open reading frame 43; OTTHUMP00000011157; OTTHUMP00000011018
• Gene ID: 3481
• mRNA Refseq: NM_000612
• Protein Refseq: NP_000603
• MIM: 147470
• UniProt ID: P01344
• Chromosome Location: 11p15.5
• Function: growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; protein binding