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Recombinant Human Iinterleukin 23, Alpha Subunit P19

Cat. No.: L23A-269H
Product Overview: Recombinant Human IL23A is expressed inHuman 293 cellsas a heterodimeric glycoprotein composed of two disulfide-linked subunits (p40 cystine linked to p19).
Description: Production in Human 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have posttranslational modifications which are not humanlike. This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4 (+) T cells, IL23 preferentially acts on memory CD4 (+) T cells.
Source: Human 293 cells.
Endotoxin: Endotoxin-free.
Purity: >95%. The protein was resolved by SDS polyacrylamide gel electrophoresis and the gelwas stained with Coomassie blue.
Activity: The specific activity was determined by the dose-dependent secretion of IL-17 from mouse splenocytes activated with 10ng/mL PMA.
Solubility: It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-6 in sterile 20mM AcOH (acetic Acid) not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage: -20℃.
Gene Name: IL23A interleukin 23, alpha subunit p19 [Homo sapiens]
Synonyms: P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388; IL23A ;interleukin-23 subunit alpha ; IL-23-A ; IL-23p19 ; IL-23 subunit alpha ; interleukin 23 p19 subunit ; interleukin-23 subunit p19 ; JKA3 induced upon T-cell activation
Gene ID: 51561
mRNA Refseq: NM_ 016584
Protein Refseq: NP_057668
MIM: 605580
UniProt ID: Q9NPF7
Chromosome Location: 12q13.3
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; protein binding

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