Active Recombinant Human Left-right Determination Factor 1

• Cat.No.: Lefty1-1915H
• Product Overview: Recombinant Human Left-right Determination Factor 1 was expressed inhuman 293 cells.

Specification

• Cat. No.: LEFTY1-1915H
• Description: Lefty (left-right determination factors) are proteins that are closely related members of the TGF-beta family of growth factors. These proteins are secreted and play a role in left-right asymmetry determination of organ systems during development. Mutations of the genes encoding these proteins have been associated with left-right axis malformations, particularly in the heart and lungs.
• Source: Human 293 cells.
• Activity: 10 to 40 ng/mL ED50.
• Purity: >90%.
• Endotoxin: Endotoxin-free.
• Molecular Mass: 38 kDa, monomer, glycosylated.
• Purity Confirmation: The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
• Activity Assay: The specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse chondrogenic cell line).

Gene Information

• Gene Name: LEFTY1 left-right determination factor 1 [ Homo sapiens ]
• Synonyms: LEFTB; LEFTYB; LEFTY1; left-right determination factor 1; left-right determination, factor B; Protein lefty-1; Left-right determination factor B; Protein lefty-B; UNQ278/PRO317
• Gene ID: 10637
• mRNA Refseq: NM_020997
• Protein Refseq: NP_066277
• MIM: 603037
• UniProt ID: O75610
• Chromosome Location: 1q42.1
• Pathway: TGF-beta signaling pathway
• Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding