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Recombinant Rat TrkA, FC Chimera

Cat. No.: Ntrk1-589R
Product Overview: Recombinant Rat TrkA was expressed inNSOCells.The recombinant mature human Trk A/Fc is a disulfide-linked homodimeric protein, Based on N-terminal.
Description: A DNA sequence encoding the signal peptide from human CD33 joined with the extracellular domain of human TrkA was fused to the Fc region of human IgG1 via a polypeptide linker.
Source: NSO Cells.
Purity: > 95%, as determined by SDS-PAGE and visualized by silver stain.
Endotoxin: < 1.0 EU per 1 μg of the enzyme as determined by the LAL method. Measured by its ability to inhibit NGF-induced proliferation of TF1 cells. The ED50 for this effect is typically 0.8-4 μg/mL in the presence of 10 ng/mL of rhNGF. The cell number is assessed in a fluorometric assay using a redox sensitive dye,
Format: Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution: It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.
Storage: Lyophilized samples are stable for up to six months at -20℃to -70℃. Upon reconstitution, this cytokine, in the presence of a carrier protein, can be stored under sterile conditions at 2 -8℃ for one month or at -20℃ to -70℃in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Gene Name: Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [ Rattus norvegicus ]
Synonyms: Ntrk;neurotrophic tyrosine kinase, receptor, type 1;Trk; Ntrk1;trk;trk-A;p140-TrkA;trkA proto-oncogene receptor;slow nerve growth factor receptor;high affinity nerve growth factor receptor
Gene ID: 59109
mRNA Refseq: NM_021589
Protein Refseq: NP_067600
UniProt ID: P35739.1
Chromosome Location: 2q34
Pathway: Endocytosis;MAPK signaling pathway;Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer
Function: protein binding

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