"BMP4" Related Products


Recombinant Human Bone Morphogenetic Protein 4

Cat. No.: BMP4-23H
Product Overview: Recombinant human BMP4 is a protein expressed and purified fromhuman 293 cellsas a glycosylated homodimer with an apparent molecular mass of 34-38 kDa.
Description: Bone Morphogenetic Protein 4 (BMP-4) is a polypeptide belonging to the TGF-β protein superfamily. BMP-4 is involved in bone and cartilage development; more specifically, in tooth and limb development fracture repair1. In human embryonic development, BMP-4 is a critical signaling molecule required for the early differentiation of the embryo and establishment of a dorsal-ventral axis 2,3. BMP-4 plays an important role in differentiation of overlying ectodermal tissue. Inhibition of the BMP-4 signal causes the ectoderm to differentiate into the neural plate. In cultured stem cells, BMP-4 plays a distinct role in mouse and human embryonic stem (ES) cells. BMP-4 supports LIF as a positive factor for mouse ES cell self-renewal4. In contrast, BMP-4 induces extra-embryonic trophoblast differentiation in human ES cells.
Source: Human 293 cells.
Purity: Greater than 95 % by SDS-PAGE.
Formulation: Lyophilized from sterile-filtered 50 mM NaOAc, pH 4.5 and 1 M NaCl containing no additives.
Endotoxin Level: < 1 EU/μg of BMP-4 as determined by the LAL method.
Biologic Activity: ED50 determined by its ability to induce alkaline phosphatase production by mouse chondrongenic ATDC-5 cells is 4.2 ng/ml.
Storage And Handling: Stemfactor™ BMP-4, Human Recombinant, is stable in the lyophilized form for six months at -20°C to -80°C. Centrifuge briefly and reconstitute BMP-4 in 4 mM HCl to prepare a working stock solution of no less than 0.1 mg/ml. Reconstituted BMP-4 should be stored in working aliquots at -20°C for up to six months. Multiple freeze and thaw cycles will result in significant loss of activity.
Gene Name: BMP4 bone morphogenetic protein 4 [ Homo sapiens ]
Synonyms: ZYME; BMP2B; BMP2B1; DVR4; MCOPS6; BMP-2B; BMP-4; Bone morphogenetic protein 4 precursor; bone morphogenetic protein 2B; bone morphogenetic protein 4; BMP4
Gene ID: 652
mRNA Refseq: NM_001202
Protein Refseq: NP_001193
MIM: 112262
UniProt ID: P12644
Chromosome Location: 14q22-q23
Function: cytokine activity. growth factor activity. heparin binding. protein binding. signal transducer activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.