Recombinant Human Nei Endonuclease VIII-like 2 (E. coli)

• Cat.No.: NEIL2-2042H
• Product Overview: Recombinant human Neil2 was expressed inE. coli, 38kDa.

Specification

• Cat. No.: NEIL2-2042H
• Description: Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene. NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
• Source: E. coli.
• Purity: 90% by SDS PAGE and Coomassie blue staining.
• Buffer Component: 20mM Tris-HCl, pH 7.5, 300mM NaCl, 10% glycerol.
• Storage: Stable for 2 years at -70°C from date of shipment. Please aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: NEIL2 nei endonuclease VIII-like 2 (E. coli) [ Homo sapiens ]
• Synonyms: nei endonuclease VIII-like 2 (E. coli); NEH2; NEI2; MGC2832; MGC4505; FLJ31644; NEIL2; nei like 2; nei like 2 (E. coli); Nei-like 2; DNA-(apurinic or apyrimidinic site) lyase Neil2; DNA glycosylase/AP lyase Neil2;EC 3.2.2.-,EC 4.2.99.18
• Gene ID: 252969
• mRNA Refseq: NM_001135746
• Protein Refseq: NP_001129218
• MIM: 608933
• UniProt ID: Q969S2
• Chromosome Location: 8p23.1
• Pathway: Base excision repair
• Function: hydrolase activity, hydrolyzing N-glycosyl compounds; DNA-(apurinic or apyrimidinic site) lyase activity; damaged DNA binding; lyase activity; metal ion binding; microtubule binding; zinc ion binding