"TNFRSF6B" Related Products


Recombinant Human TNFRSF6B, Fc Chimera

Cat. No. : TNFRSF6B-2078H
Product Overview : Recombinant Human TNFRSF6B is produced inHEK 293 Cells.The extracellular domain of human DcR3 (decoy receptor 3) (aa 1-246) is fused to the Fc portion of human IgG1. MW=58kDa.
Description : This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5" UTR, have been observed for this gene.
Source : HEK 293 Cells.
Concentration : 1mg/ml after reconstitution.
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 50µl sterile water.
Specificity : Binds human LIGHT. Does not bind human FasL.
Application : Detection of human LIGHT and TL1A (VEGI) in combination with PAb to human IgG1.
Purity : ≥90% (SDS-PAGE).
Storage : Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles.
Gene Name : TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens ]
Synonyms : TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; M68; TR6; DCR3; DJ583P15.1.1; TNFRSF6B; tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
Gene ID : 8771
mRNA Refseq : NM_003823
Protein Refseq : NP_003814
MIM : 603361
UniProt ID : O95407
Chromosome Location : 20q13.3
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity

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