Recombinant Human TNFSF13, FLAG-tagged

• Cat.No.: TNFSF13-2091H
• Product Overview: Recombinant HumanTNFSF13 Produced inHEK 293 cells. The extracellular domain of human APRIL (aa 88-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG-tag. MW=34kDa (SDS-PAGE).

Specification

• Cat. No.: TNFSF13-2091H
• Description: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM.
• Source: HEK 293 cells.
• Concentration: 0.1mg/ml after reconstitution.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
• Specificity: Binds to human and mouse BCMA and TACI. Binds to proteoglycans.
• Biological Activity: Stimulates proliferation of serum-starved NIH 3T3 cells. Stimulates B cell proliferation.
• Long Term Storage: -20°C.
• Handling: Stable for at least 6 months after receipt when stored at -20°C.
• Stability: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Gene Information

• Gene Name: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 [ Homo sapiens ]
• Synonyms: TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; APRIL; CD256; TALL2; TRDL-1; ligand; UNQ383/PRO715; TALL-2; TNF-related death ligand 1; a proliferation inducing ligand; a proliferation-inducing ligand; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2; tumor necrosis factor ligand superfamily member 13 epsilon; tumor necrosis factor (ligand) superfamily member 13 transcript variant delta
• Gene ID: 8741
• mRNA Refseq: NM_003808
• Protein Refseq: NP_003799
• MIM: 604472
• UniProt ID: O75888
• Chromosome Location: 17p13.1
• Pathway: Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production
• Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding