Recombinant Human Sp1 Transcription Factor
Cat.No. : | SP1-590H |
Product Overview : | Recombinant human SP1 protein was expressed inSf9 insect cells. |
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Cat. No. : | SP1-590H |
Description : | SP1 belongs to the family of zinc finger DNA binding proteins in mammalian cells. This protein mediates transcriptional activity through specific DNA sequences that are found in a number of viral and cellular gene promoters. SP1 has been shown to associate with other mammalian gene coactivator proteins to regulate gene transcription. |
Source : | Sf9 insect cells. |
Formulation : | 15 ug of recombinant SP1 protein in 5uM ZnSO4, 50 mM KCl, 2mM DTT, 12 mM HEPES-KOH (pH 7.5), 6 mM MgCl2, 0.1% NP40 and 50% glycerol. |
Applications : | Useful for the stimulation of LSD1 enzyme activity. |
Storage : | Store at -70º C. Avoid multiple freeze/thaw cycles. |
Pathways : | Huntington"s disease; TGF-beta signaling pathway |
Gene Name : | SP1 Sp1 transcription factor [ Homo sapiens ] |
Synonyms : | SP1; Sp1 transcription factor; Sp1 transcription factor; specificity protein 1; TSFP1; Transcription factor Sp1 |
Gene ID : | 6667 |
mRNA Refseq : | NM_003109 |
Protein Refseq : | NP_003100 |
MIM : | 189906 |
UniProt ID : | P08047 |
Chromosome Location : | 12q13.1 |
Function : | DNA binding; RNA polymerase II transcription factor activity; double-stranded DNA binding; histone deacetylase binding; metal ion binding; promoter binding; protein C-terminus binding; protein homodimerization activity; transcription activator activity; transcription factor activity; zinc ion binding |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSP1 plays a role in immune response by regulating the expression of genes involved in inflammation and immune cell function. Its modulation can influence the immune system's response to various stimuli.
Yes, SP1 is implicated in cardiovascular diseases by regulating genes involved in vascular smooth muscle cell proliferation and migration. Targeting SP1 may offer therapeutic avenues for cardiovascular conditions.
Yes, SP1 has been implicated in neurodegenerative diseases. Its role in regulating genes related to neuronal survival and death makes it a target for exploring therapeutic interventions in conditions like Alzheimer's disease.
Yes, elevated levels of SP1 have been observed in certain cancers. Detection of SP1 expression can potentially serve as a diagnostic marker, aiding in the early identification of cancer.
SP1 regulates the expression of genes involved in angiogenesis, the formation of new blood vessels. Increased SP1 activity is associated with enhanced angiogenesis, which can be critical in wound healing and tumor growth.
Customer Reviews (3)
Write a reviewIn addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the SP1 protein.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.
By relying on the SP1 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.
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