Expand| Cat.No. : | NOS2-611H |
| Product Overview : | Recombinant Human NOS2(a.a. 2 – 1153) fussed with His-Flag tag at N-terminal was expressed in a baculovirus infected Sf9 cell expression system. |
| Description : | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. |
| Source : | Insect cell |
| Species : | Human |
| Tag : | His-Flag |
| Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/µl FLAG peptide, and 20% glycerol. |
| Molecular Mass : | MW= 133 kDa |
| AA Sequence : | MHHHHHHDYKDDDDKACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPT PPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSN LQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDP ANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANM LLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQ NVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQ DEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYR LSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGA SQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKAL SSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTP HQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKW KFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCS TWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRR PDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVA HTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPSSLEMSAL |
| Purity : | ≥95% |
| Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Stability : | >6 months at –80 centigrade |
| Concentration : | 0.15 mg/ml |
| Warning : | Avoid freeze/thaw cycles. |
| Gene Name : | NOS2 nitric oxide synthase 2, inducible [ Homo sapiens ] |
| Official Symbol : | NOS2 |
| Synonyms : | NOS; INOS; NOS2A; HEP-NOS; nitric oxide synthase, inducible; NOS type II; NOS, type II; hepatocyte NOS; inducible NO synthase; inducible NOS; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2 |
| Gene ID : | 4843 |
| mRNA Refseq : | NM_000625 |
| Protein Refseq : | NP_000616 |
| MIM : | 163730 |
| UniProt ID : | P35228 |
| Chromosome Location : | 17q11.2 |
| Pathway : | AGE/RAGE pathway, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Calcium signaling pathway, conserved biosystem |
| Function : | FMN binding; NADPH-hemoprotein reductase activity; iron ion binding |
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