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Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged

Cat.No. : GUCY1A3-627H
Product Overview : Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3 is produced inSf9 cellsfused at the C-terminus to a His-tag. MW= 70kDa-86kDa.
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Cat. No. : GUCY1A3-627H
Description : Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Source : Sf9 cells.
Purity : ≥90% (SDS-PAGE).
Concentration : 0.4mg/ml.
Formulation : Liquid. In 40mM TEA, pH 7.4 containing 2mM DTT, 1mM MgCl2 and 30% glycerol.
Application : Biophysical and enzymatic studies and drug screening.
Specificity : ≥0.075µmol/mg/min.
Storage And Stability : -80°C. We do not recommend to store for longer periods after opening and thawing of the product. Avoid freeze/thaw cycles.
Gene Name : GUCY1A3 guanylate cyclase 1, soluble, alpha 3 [ Homo sapiens ]
Synonyms : GUCY1A3; guanylate cyclase 1, soluble, alpha 3; GUCA3; GC-SA3; GUC1A3; GUCSA3; GUCY1A1; guanylate cyclase soluble subunit alpha-3; GCS-alpha-1; GCS-alpha-3; GC-S-alpha-1; soluble guanylate cyclase large subunit; EC 4.6.1.2
Gene ID : 2982
mRNA Refseq : NM_000856
Protein Refseq : NP_000847
MIM : 139396
UniProt ID : Q02108
Chromosome Location : 4q31.3-q33; 4q31.1-q31.2
Pathway : Gap junction; Long-term depression; Purine metabolism; Vascular smooth muscle contraction
Function : GTP binding; guanylate cyclase activity; heme binding; ion binding; nucleotide binding; protein heterodimerization activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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