Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged GUCY1A3-627H

Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged

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Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged

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Cat. No. : GUCY1A3-627H
Product Overview : Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3 is produced inSf9 cellsfused at the C-terminus to a His-tag. MW= 70kDa-86kDa.
Description : Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Source : Sf9 cells.
Purity : ≥90% (SDS-PAGE).
Concentration : 0.4mg/ml.
Formulation : Liquid. In 40mM TEA, pH 7.4 containing 2mM DTT, 1mM MgCl2 and 30% glycerol.
Application : Biophysical and enzymatic studies and drug screening.
Specificity : ≥0.075µmol/mg/min.
Storage And Stability : -80°C. We do not recommend to store for longer periods after opening and thawing of the product. Avoid freeze/thaw cycles.
Gene Name : GUCY1A3 guanylate cyclase 1, soluble, alpha 3 [ Homo sapiens ]
Synonyms : GUCY1A3; guanylate cyclase 1, soluble, alpha 3; GUCA3; GC-SA3; GUC1A3; GUCSA3; GUCY1A1; guanylate cyclase soluble subunit alpha-3; GCS-alpha-1; GCS-alpha-3; GC-S-alpha-1; soluble guanylate cyclase large subunit; EC 4.6.1.2
Gene ID : 2982
mRNA Refseq : NM_000856
Protein Refseq : NP_000847
MIM : 139396
UniProt ID : Q02108
Chromosome Location : 4q31.3-q33; 4q31.1-q31.2
Pathway : Gap junction; Long-term depression; Purine metabolism; Vascular smooth muscle contraction
Function : GTP binding; guanylate cyclase activity; heme binding; ion binding; nucleotide binding; protein heterodimerization activity; receptor activity

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