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Recombinant Human PRMP1, His-tagged

Cat. No.: PRMP1-678H
Product Overview: Recombinant human PRMT1 produced inSF21 cellsis fused to a His-tag.
Description: Protein arginine N-methyltransferase 1(PRMT1) is a type I methyltransferase that transfers a methyl group from S-adenosylmethionine to guanidino nitrogens of arginine residues to form monomethylarginine and asymmetric dimethylarginine. Functions of type I arginine methylation in proteins may include regulation of transcription, modulation of the affinity of nucleic acid-binding proteins, regulation of interferon signaling pathways, and targeting of nuclear proteins.
Source/Host: SF21 cells.
Application: Study of enzyme kinetics and regulation, dephosphorylation of target substrates, and inhibitor screening.
Concentration: 0.5mg/ml.
Purity: ≥90% (SDS-PAGE).
Specific Activity: 50-100ng are required for standard HAT assay.
Formulation: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
Long Term Storage: -80°C.
Handling: Avoid freeze/thaw cycles. After opening, prepare aliquots and store in liquid nitrogen.
Gene Name: PRMT1 protein arginine methyltransferase 1 [ Homo sapiens ]
Synonyms: HMT1 hnRNP methyltransferase-like 2 isoform 3; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2; PRMT1; HMT1 hnRNP methyltransferase-like 2; interferon receptor 1-bound protein 4; protein arginine N-methyltransferase 1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; EC 2.1.1.; HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae); protein arginine methyltransferase 1
Gene ID: 3276
mRNA Refseq: NM_198318
Protein Refseq: NP_938074
MIM: 602950
UniProt ID: Q8WUW5
Chromosome Location: 19q13.3
Function: N-methyltransferase activity; protein binding; transferase activity

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