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Recombinant Human Granulin, FLAG-tagged

Cat. No. : GRN-2379H
Product Overview : Recombinant human progranulin (aa 1-593) produced inHEK 293 cellsis fused at the C-terminus to a FLAG-tag.
Description : Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
Source/Host : HEK 293 cells.
Concentration : 1mg/ml.
Purity : ≥90% (SDS-PAGE).
Endotoxin Content : <0.1EU/µg protein (LAL-test).
Formulation : Liquid. 0.2µm-filtered solution in PBS.
Long Term Storage : -20°C
Use/Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Handling : After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : GRN granulin [ Homo sapiens ]
Synonyms : GRN; granulin; GEP; GP88; PEPI; PGRN; PCDGF; GRN; progranulin; PEPI; Acrogranin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin A; Granulin C; Granulin D; Granulin E; granulin-epithelin; proepithelin; progranulin; PC cell-derived growth factor
Gene ID : 2896
mRNA Refseq : NM_002087
Protein Refseq : NP_002078
MIM : 138945
UniProt ID : P28799
Chromosome Location : 17q21.32
Function : cytokine activity; growth factor activity

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