Active Recombinant Human CSF1
Cat.No. : | CSF1-418H |
Product Overview : | Macrophage Colony Stimulating Factor Human Recombinant produced in E.coli is a disulfide linked homodimer, glycosylated, polypeptide chain containing 2 x 149 amino acids and having a total molecular mass of 42 kDa. MCSF is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. |
Source : | Baculovirus infected Silkworm |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. The lyophilized protein (1mg/ml) was lyophilized with 20mM phosphate buffer, 1% HSA and 3% manntiol. |
Bio-activity : | The ED50, calculated by the dose-dependant stimulation of the proliferation of murine M-NFS-60 indicator cells was found < 3ng/ml, corresponding to a specific activity of less than 333,333.33units/mg. |
Molecular Mass : | 42 kDa |
AA Sequence : | EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQ. |
Purity : | Greater than 95.0% as determined by RP-HPLC and SDS-PAGE. |
Storage : | Lyophilized Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCSF should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. |
Reconstitution : | It is recommended to reconstitute the lyophilized M-CSF in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Gene Name : | CSF1 colony stimulating factor 1 (macrophage) [ Homo sapiens (human) ] |
Official Symbol : | CSF1 |
Synonyms : | CSF1; MCSF; CSF-1; colony stimulating factor 1 (macrophage); macrophage colony-stimulating factor 1; lanimostim; NP_000748.3; EC 2.7.10.1; NP_757349.1; NP_757350.1; NP_757351.1 |
Gene ID : | 1435 |
mRNA Refseq : | NM_000757 |
Protein Refseq : | NP_000748 |
MIM : | 120420 |
UniProt ID : | P09603 |
Chromosome Location : | 1q21-p13 |
Pathway : | Cytokine-cytokine receptor interaction; Rheumatoid arthritis; Signaling events mediated by TCPTP |
Function : | cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding |
Products Types
◆ Recombinant Protein | ||
CSF1-41H | Active Recombinant Human CSF1 Protein, Animal Free | +Inquiry |
Csf1-18M | Active Recombinant Mouse Csf1 Protein (Lys33-Pro187), C-His tagged, Animal-free, Carrier-free | +Inquiry |
CSF1-198H | Recombinant Human CSF1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
CSF1-2158H | Recombinant Human CSF1 Protein, His-tagged | +Inquiry |
CSF1-4398B | Recombinant Bovine CSF1 Protein | +Inquiry |
◆ Lysates | ||
CSF1-001MCL | Recombinant Mouse CSF1 cell lysate | +Inquiry |
CSF1-1934HCL | Recombinant Human CSF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.
Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.
Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.
Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.
Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.
Customer Reviews (3)
Write a reviewThe CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.
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