| Cat. No.: | PDP1-698H |
| Product Overview: | Recombinant Human PDP1 with a His tag is expressed inBacteriaand column-purified. |
| Description: | PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH. |
| Source: | Bacteria. |
| Storage: | Store at -80°C. |
| Gene Name: | PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 [ Homo sapiens ] |
| Synonyms: | PDP1; pyruvate dehyrogenase phosphatase catalytic subunit 1; PDP 1; PDPC 1; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; protein phosphatase 2C, magnesium-dependent, catalytic subunit; pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase; pyruvate dehydrogenase phosphatase catalytic subunit 1; PDH; PDP; PDPC; PPM2C; FLJ32517; FLJ56179; MGC119646; EC 3.1.3.43 |
| Gene ID: | 54704 |
| mRNA Refseq: | NM_001161778 |
| Protein Refseq: | NP_001155250 |
| MIM: | 605993 |
| UniProt ID: | Q9P0J1 |
| Chromosome Location: | 8q22.1 |
| Pathway: | Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle |
| Function: | [pyruvate dehydrogenase (lipoamide)] phosphatase activity; calcium ion binding; hydrolase activity; magnesium-dependent protein serine/threonine phosphatase activity; protein complex binding |
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