"PLAU" Related Products


Recombinant Human Plasminogen Activator, Urokinase

Cat. No. : PLAU-2467H
Product Overview : Recombinant Human plasminogen activator, urokinase was expressed inInsect Cells.MW=18.5 KDa.
Description : Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Source : Insect Cells.
Concentration : 1.0 mg/ml.
Volume : 0.1 ml.
Buffer : 0.1 M Hepes; 0.1 M NaCl; pH 7.4.
Form : Frozen liquid.
Shipping Information : Recommended Storage: -70℃;Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.
PDB rendering based on 1c5w. :

Gene Name : PLAU plasminogen activator, urokinase [ Homo sapiens ]
Synonyms : PLAU; plasminogen activator, urokinase; ATF; UPA; URK; u-PA; U-plasminogen activator; plasminogen activator, urinary; urokinase-type plasminogen activator; EC; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B
Gene ID : 5328
mRNA Refseq : NM_001145031
Protein Refseq : NP_001138503
MIM : 191840
UniProt ID : P00749
Chromosome Location : 10q24
Pathway : Complement and coagulation cascades
Function : peptidase activity; serine-type endopeptidase a activity

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