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Recombinant Human Plasminogen Activator, Urokinase

Cat.No. : PLAU-2467H
Product Overview : Recombinant Human plasminogen activator, urokinase was expressed inInsect Cells.MW=18.5 KDa.
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Cat. No. : PLAU-2467H
Description : Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Source : Insect Cells.
Concentration : 1.0 mg/ml.
Volume : 0.1 ml.
Buffer : 0.1 M Hepes; 0.1 M NaCl; pH 7.4.
Form : Frozen liquid.
Shipping Information : Recommended Storage: -70℃;Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.
Gene Name : PLAU plasminogen activator, urokinase [ Homo sapiens ]
Synonyms : PLAU; plasminogen activator, urokinase; ATF; UPA; URK; u-PA; U-plasminogen activator; plasminogen activator, urinary; urokinase-type plasminogen activator; EC 3.4.21.73; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B
Gene ID : 5328
mRNA Refseq : NM_001145031
Protein Refseq : NP_001138503
MIM : 191840
UniProt ID : P00749
Chromosome Location : 10q24
Pathway : Complement and coagulation cascades
Function : peptidase activity; serine-type endopeptidase a activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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