|Cat. No. :
|Product Overview :
||Recombinant Human plasminogen activator, urokinase was expressed inInsect Cells.MW=18.5 KDa.
||Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
||0.1 M Hepes; 0.1 M NaCl; pH 7.4.
|Shipping Information :
||Recommended Storage: -70℃;Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.
|PDB rendering based on 1c5w. :