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Recombinant Human Plasminogen Activator, Urokinase

Cat. No.: PLAU-2467H
Product Overview: Recombinant Human plasminogen activator, urokinase was expressed inInsect Cells.MW=18.5 KDa.
Description: Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Source: Insect Cells.
Concentration: 1.0 mg/ml.
Volume: 0.1 ml.
Buffer: 0.1 M Hepes; 0.1 M NaCl; pH 7.4.
Form: Frozen liquid.
Shipping Information: Recommended Storage: -70℃;Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.
Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens ]
Synonyms: PLAU; plasminogen activator, urokinase; ATF; UPA; URK; u-PA; U-plasminogen activator; plasminogen activator, urinary; urokinase-type plasminogen activator; EC 3.4.21.73; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B
Gene ID: 5328
mRNA Refseq: NM_001145031
Protein Refseq: NP_001138503
MIM: 191840
UniProt ID: P00749
Chromosome Location: 10q24
Pathway: Complement and coagulation cascades
Function: peptidase activity; serine-type endopeptidase a activity

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