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Recombinant Human Protein Kinase C, Beta

Cat. No.: PRKCB-649H
Product Overview: Recombinant Human PRKCB is produced inBaculoviral insect expression system.
Description: PKCβI is a member of the PKC family (phospholipid-dependent serine/threonine kinase) and is highly related to PKCβ II. Unlike the mature PKCβ II mRNA and protein, which rapidly increase following acute insulin treatment, the PKCβI mRNA and protein levels remain unchanged. The stable overexpression of PKCbetaII, but not PKCβI, leads to insulin-stimulated glucose uptake into cells. Upon stimulation of B lymphocytes and mast cells, Syk regulates Btk, and Btk selectively regulates enzymatic activity of PKCβI. Specific regulation of PKCβI by Btk is consistent with the selective association of Btk with PKCβI.
Source: Baculoviral insect expression system.
Format: Purified, Liquid.
Concentration: 20ug/ml.
Buffer: Suspended in SDS/mercaptoethanol sample buffer with a bromophenol blue dye marker.
Applications: Suitable for use as a standard in Western blot using enhanced chemiluminescence. Use 2-5ul directly from vial (no dilution necessary). For blots using less sensitive substrates, such as alkaline phosphatase, larger amount of protein should be loaded onto the gel. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Inactivation: Not applicable.
Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
Storage: Short term (up to 1 year) store at –20°C. Long term, store at –70°C.
Gene Name: PRKCB protein kinase C, beta [ Homo sapiens ]
Synonyms: PRKCB; protein kinase C, beta; PKCB; PRKCB1; PRKCB2; MGC41878; PKC-beta; Protein kinase C beta type; EC 2.7.11.13; PKC-B; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide
Gene ID: 5579
mRNA Refseq: NM_002738
Protein Refseq: NP_002729
MIM: 176970
UniProt ID: P05771
Chromosome Location: 16p11.2
Pathway: B cell receptor signaling pathway; Calcium signaling pathway; Chemokine signaling pathway; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Glioma; GnRH signaling pathway; Leukocyte transendothelial migration; Long-term depression; Long-term potentiation; Non-small cell lung cancer; Pathways in cancer; Phosphatidylinositol signaling system; Tight junction; VEGF signaling pathway; Vascular smooth muscle contraction; Vibrio cholerae infection; Wnt signaling pathway; Hemostasis; Synaptic Transmission
Function: ATP binding; calcium ion binding; nucleotide binding; protein binding; protein kinase C activity; transferase activity; zinc ion binding

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