Recombinant Human ACE, His-tagged


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Recombinant Human ACE, His-tagged

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Cat. No. : ACE-744H
Product Overview : Recombinant human ACE ectodomain (amino acids 30-1261) fused at the C-terminus to a His•Tag sequence and expressed inNSO cells. By SDS-PAGE, the apparent molecular weight of the glycosylated protein appears larger to be than 120 kDa under both reducing and non-reducing conditions.
Description : ACE is a zinc metallopeptidase that cleaves the C-terminal dipeptide from angiotensin I to produce the potent vasopressor octapeptide angiotensin II. ACE gene polymorphism has been a recent topic in Alzheimer"s disease studies. ACE is a type I membrane protein and exists in two isoforms, somatic and germinal.
Source : Mammalian cells
Purity : ≥95% by SDS-PAGE.
Form : Liquid.In 75 mM NaCl, 12.5 mM Tris, 500 nM ZnCl2, 40% glycerol, pH 7.5. Please refer to vial label for lot-specific concentration.
Endotoxins : ≤1.0 EU/µg ACE.
Specific Activity : ≥1 unit/µg protein.
Unit Definition : One unit is defined as the amount of enzyme that will cleave 1 nmol MCA-RPPGFSAFK(DNP)-OH per min at 25°C, pH 6.5.
Toxicity : Standard Handling(MSDS available upon request).
Storage : ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70°C).
Gene Name : ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [ Homo sapiens ]
Synonyms : ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; DCP; ACE1; DCP1; CD143; MVCD3; MGC26566; angiotensin-converting enzyme; kininase II; peptidase P; CD143 antigentesticular ECA; carboxycathepsin; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; angiotensin converting enzyme, somatic isoform; EC; Angiotensin-converting enzyme, soluble form
Gene ID : 1636
mRNA Refseq : NM_000789
Protein Refseq : NP_000780
MIM : 106180
UniProt ID : P12821
Chromosome Location : 17q23.3
Pathway : Chagas disease; Hypertrophic cardiomyopathy (HCM); Renin-angiotensin system
Function : actin binding; bradykinin receptor binding; carboxypeptidase activity; chloride ion binding; drug binding; metal ion binding; metallopeptidase activity; peptidase activity; peptide binding; peptidyl-dipeptidase activity; protein binding; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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