Recombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme)

• Cat.No.: FURIN-755H
• Product Overview: Recombinant human furin was expressed in vaccinia virus (VV:hFUR713t) infectedBSC-40 cells. MW = 81 kDa.

Specification

• Species: Human
• Source: BSC40
• Tag: Non
• Description: Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like pro-hormone convertase (PC) family. Members of this family cleave pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins. The preparation was subjected to UV irradiation for 5 minutes to inactivate any residual virus.
• Form: Liquid. In 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
• Unit Definition: One unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
• Toxicity: Standard Handling (MSDS available upon request).
• Storage: ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).

Gene Information

• Gene Name: FURIN furin (paired basic amino acid cleaving enzyme) [ Homo sapiens ]
• Synonyms: FURIN; furin (paired basic amino acid cleaving enzyme); FUR; PACE; SPC1; PCSK3; FES upstream region; dibasic processing enzyme; dibasic-processing enzyme; furin, membrane associated receptor protein; proprotein convertase subtilisin/kexin type 3; paired basic amino acid residue-cleaving enzyme; EC 3.4.21.75; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)
• Gene ID: 5045
• mRNA Refseq: NM_002569
• Protein Refseq: NP_002560
• MIM: 136950
• UniProt ID: P09958
• Chromosome Location: 15q26.1
• Pathway: Metabolism of proteins; Signaling by Notch; Signaling by PDGF; Signaling by TGF beta; Signalling by NGF
• Function: endopeptidase activity; metal ion binding; nerve growth factor binding; peptidase activity; peptide binding; protease binding; protein binding; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity