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Recombinant Human GZMB

Cat. No. : GZMB-757H
Product Overview : Recombinant human granzyme B was expressed inE. coli.MW = 25511 Da.
Description : Granzyme B (GzmB) is a serine protease that is involved in cytotoxic T lymphocyte-induced (CTL) cell death. It is reported to participate in the perforation of target cells and initiation of protelolysis that leads apoptosis. Similar to caspases, granzyme B preferentially cleaves substrate proteins with aspartic acid in the P1 position.
Source : E.coli.
Form : Liquid. In TBS, 50% glycerol.
Specific Activity : ≥7.0 units/µg protein.
Unit Definition : One unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-pNA per min 25℃, pH 8.0.
Toxicity : Standard Handling (MSDS available upon request).
Storage : ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).
PDB rendering based on 1fq3. :

Gene Name : GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [ Homo sapiens ]
Synonyms : GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; fragmentin 2; cathepsin G-like 1; T-cell serine protease 1-3E; cytotoxic serine protease B; EC 3.4.21.79; Granzyme-2; Cytotoxic T-lymphocyte proteinase 2; Human lymphocyte protein; Lymphocyte protease; C11; Fragmentin-2; GRB
Gene ID : 3002
mRNA Refseq : NM_004131
Protein Refseq : NP_004122
MIM : 123910
UniProt ID : P10144
Chromosome Location : 14q11.2
Pathway : Allograft rejection; Autoimmune thyroid disease; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus
Function : peptidase activity; protein binding; serine-type endopeptidase activity

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