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Recombinant Human GZMB

Cat.No. : GZMB-757H
Product Overview : Recombinant human granzyme B was expressed inE. coli.MW = 25511 Da.
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Cat. No. : GZMB-757H
Description : Granzyme B (GzmB) is a serine protease that is involved in cytotoxic T lymphocyte-induced (CTL) cell death. It is reported to participate in the perforation of target cells and initiation of protelolysis that leads apoptosis. Similar to caspases, granzyme B preferentially cleaves substrate proteins with aspartic acid in the P1 position.
Source : E.coli.
Form : Liquid. In TBS, 50% glycerol.
Specific Activity : ≥7.0 units/µg protein.
Unit Definition : One unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-pNA per min 25℃, pH 8.0.
Toxicity : Standard Handling (MSDS available upon request).
Storage : ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).
Gene Name : GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [ Homo sapiens ]
Synonyms : GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; fragmentin 2; cathepsin G-like 1; T-cell serine protease 1-3E; cytotoxic serine protease B; EC 3.4.21.79; Granzyme-2; Cytotoxic T-lymphocyte proteinase 2; Human lymphocyte protein; Lymphocyte protease; C11; Fragmentin-2; GRB
Gene ID : 3002
mRNA Refseq : NM_004131
Protein Refseq : NP_004122
MIM : 123910
UniProt ID : P10144
Chromosome Location : 14q11.2
Pathway : Allograft rejection; Autoimmune thyroid disease; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus
Function : peptidase activity; protein binding; serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some potential future applications of GZMB in medicine? 02/05/2020

GZMB may be used in the development of targeted therapies for viral infections and various immune-related disorders.

How is GZMB protein clinically relevant in cancer treatment? 07/28/2018

GZMB can be used in cancer immunotherapy to target and eliminate cancer cells.

What are the challenges in using GZMB in cancer immunotherapy? 09/14/2016

One challenge is to ensure that GZMB selectively targets cancer cells without causing harm to healthy cells.

What types of cancer can be targeted using GZMB-based therapies? 07/24/2016

GZMB-based therapies can be used against various types of cancer, including leukemia, lymphoma, and solid tumors.

Can GZMB be used in autoimmune disease treatment? 03/22/2016

GZMB's role in autoimmune diseases is complex. It can contribute to tissue damage in some autoimmune conditions, but its use in treatment is not common.

Customer Reviews (3)

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Reviews
11/01/2020

    I am delighted to express my complete satisfaction with the quality of GZMB protein, as it precisely suits my experimental requirements.

    08/29/2017

      Their knowledgeable team has been readily available to address any concerns or queries, providing effective solutions and guidance whenever needed.

      07/28/2017

        I have full confidence in the GZMB protein and the exceptional support provided by the manufacturer, making it my top recommendation for researchers seeking a high-quality protein for their experimental needs.

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