"IKBKB" Related Products


Recombinant Human IKBKB, His-S

Cat. No. : IKBKB-760H
Product Overview : Recombinant Human IKBKB (amino acids 1-756) was fused at the N-terminus with His•Tag and S•Tag sequences and expressed inS.frugiperdainsect cells.MW = 88 kDa.
Description : IKKβ is the principal kinase responsible for phosphorylating IκBα, the regulatory subunit of NF-κB transcription factor. Phosphorylation of IκBα leads to its ubiquitination and proteasome degradation, which allows results in the rapid translocation of NF-κB to the nucleus and transcriptional activation of NF-κB-dependent genes.
Source : S.frugiperda.
Purity : ≥80% by SDS-PAGE.
Form : Liquid. In 50 mM L-Arg, 50 mM L-Glu, 50 mM NaCl, 20 mM HEPES, 2 mM DTT, 1 mM EDTA, 50% glycerol, 0.03% BRIJ 35 Detergent, pH 7.5.
Specific Activity : ≥50 units/mg protein.
Unit Definition : One unit is defined as the amount of enzyme that will convert 1 nmol ATP to ADP per min per mg protein at 37°C.
Storage : ≤ -70℃. Avoid freeze/thaw.
Gene Name : IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ]
Synonyms : IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; EC
Gene ID : 3551
mRNA Refseq : NM_001190720
Protein Refseq : NP_001177649
MIM : 603258
UniProt ID : O14920
Chromosome Location : 8p11.2
Pathway : Acute myeloid leukemia; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chagas disease; Chemokine signaling pathway; Chronic myeloid leukemia; Cytosolic DNA-sensing pathway; Epithelial cell signaling in Helicobacter pylori infection; Insulin signaling pathway; MAPK signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Shigellosis; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus
Function : ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein binding; protein heterodimerization activity; transcription activator activity; transferase activity

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