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Recombinant Rat Insulin Degrading Enzyme, His-tagged

Cat. No. : Ide-761R
Product Overview : Recombinant rat insulin degrading enzyme was fused to a His•Tag sequence and expressed inS. frugiperdainsect cells.MW = 110 kDa.
Description : Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. This discovery revealed considerable amino acid sequence homology between IDE and the previously characterized bacterial protease pitrilysin, suggesting a common proteolytic mechanism.
Source : S. frugiperda.
Purity : ≥90% by SDS-PAGE.
Form : Liquid. In 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
Specific Activity : ≥3 U/mg protein.
Unit Definition : One unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
Specificity : ≥4 units/mg protein.
Storage : ≤ -70℃. Avoid freeze/thaw.
PDB rendering based on 2g47. :

Gene Name : Ide insulin degrading enzyme [ Rattus norvegicus ]
Synonyms : Ide; insulin degrading enzyme; INSDEGM; insulin-degrading enzyme; insulysin; insulinase; insulin protease; EC 3.4.24.56
Gene ID : 25700
mRNA Refseq : NM_013159
Protein Refseq : NP_037291
UniProt ID : P35559
Chromosome Location : 1q53
Pathway : Alzheimer"s disease
Function : ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; insulin binding; metal ion binding; metalloendopeptidase activity; peptidase activity; nucleotide binding; peptide hormone binding; protein binding; protein homodimerization activity; zinc ion binding

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