Recombinant Rat Insulin Degrading Enzyme, His-tagged
Cat.No. : | Ide-761R |
Product Overview : | Recombinant rat insulin degrading enzyme was fused to a His•Tag sequence and expressed inS. frugiperdainsect cells.MW = 110 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Ide-761R |
Description : | Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. This discovery revealed considerable amino acid sequence homology between IDE and the previously characterized bacterial protease pitrilysin, suggesting a common proteolytic mechanism. |
Source : | S. frugiperda. |
Purity : | ≥90% by SDS-PAGE. |
Form : | Liquid. In 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3. |
Specific Activity : | ≥3 U/mg protein. |
Unit Definition : | One unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3. |
Specificity : | ≥4 units/mg protein. |
Storage : | ≤ -70℃. Avoid freeze/thaw. |
Gene Name : | Ide insulin degrading enzyme [ Rattus norvegicus ] |
Synonyms : | Ide; insulin degrading enzyme; INSDEGM; insulin-degrading enzyme; insulysin; insulinase; insulin protease; EC 3.4.24.56 |
Gene ID : | 25700 |
mRNA Refseq : | NM_013159 |
Protein Refseq : | NP_037291 |
UniProt ID : | P35559 |
Chromosome Location : | 1q53 |
Pathway : | Alzheimer"s disease |
Function : | ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; insulin binding; metal ion binding; metalloendopeptidase activity; peptidase activity; nucleotide binding; peptide hormone binding; protein binding; protein homodimerization activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
IDE-2011R | Recombinant Rhesus Macaque IDE Protein, His (Fc)-Avi-tagged | +Inquiry |
Ide-1644M | Recombinant Mouse Ide Protein, His-tagged | +Inquiry |
IDE-2639R | Recombinant Rat IDE Protein, His (Fc)-Avi-tagged | +Inquiry |
IDE-07H | Active Recombinant Human IDE Protein (42-1019aa), C-His tagged | +Inquiry |
Ide-1211M | Recombinant Mouse Ide Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
IDE-5308HCL | Recombinant Human IDE 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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