"CDK5R1" Related Products

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Recombinant Bovine CDK5R1, GST-tagged

Cat. No.: CDK5R1-687B
Product Overview: Recombinant bovine cleaved Cdk5 activator (p35) fused to GST was expressed inE. coli.It is produced as a 35 kDa precursor and further cleaved into the 25 kDa form of the protein. MW = 51 kDa.
Description: Cleaved Cdk5 activator is an essential regulating subunit of cdk5. Aberrant Cdk5 activity has been implicated in a number of neurodegenerative diseases such as Alzheimer"s disease, amyotrophic lateral sclerosis, and Parkinson"s disease, where abnormal phosphorylation of tau and/or neurofilaments has been observed. One vial contains sufficient material for approximately 25 reactions.
Source: E. coli.
Form: Liquid. In 25 mM Tris-HCl, 100 µM DTT, 30% glycerol, pH 7.4. Please refer to vial label for lot-specific concentration.
Unit Definition: One unit is defined as the amount of protein that when reconstituted with Cdk5 will transfer 1 pmol of phosphate to Histone H1 peptide (9-18) per min at 30°C, pH 7.2.
Specific Activity: ≥100,000 units/mg protein.
Toxicity: Standard Handling (MSDS available upon request).
Storage: -20°C . Avoid freeze/thaw Following initial thaw, aliquot and freeze (-20°C).
Gene Name: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [ Bos taurus ]
Synonyms:
cyclin-dependent kinase 5, regulatory subunit 1 (p35); P25/P35; cyclin-dependent kinase 5 activator 1; p23; CDK5 activator 1; TPKII regulatory subunit; tau protein kinase II 23 kDa subunit; cyclin-dependent kinase 5 regulatory subunit 1
Gene ID: 282173
mRNA Refseq: NM_174512
Protein Refseq: NP_776937
UniProt ID: Q28199
Chromosome Location: 19
Pathway: Alzheimer"s disease
Function: cadherin binding; calcium ion binding; kinase activity; protein binding; cyclin-dependent protein kinase 5 activator activity; protein serine/threonine kinase activator activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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