Recombinant Bovine CDK5R1, GST-tagged

• Cat.No.: CDK5R1-687B
• Product Overview: Recombinant bovine cleaved Cdk5 activator (p35) fused to GST was expressed inE. coli.It is produced as a 35 kDa precursor and further cleaved into the 25 kDa form of the protein. MW = 51 kDa.

Specification

• Species: Bovine
• Source: E.coli
• Tag: GST
• Description: Cleaved Cdk5 activator is an essential regulating subunit of cdk5. Aberrant Cdk5 activity has been implicated in a number of neurodegenerative diseases such as Alzheimer"s disease, amyotrophic lateral sclerosis, and Parkinson"s disease, where abnormal phosphorylation of tau and/or neurofilaments has been observed. One vial contains sufficient material for approximately 25 reactions.
• Form: Liquid. In 25 mM Tris-HCl, 100 µM DTT, 30% glycerol, pH 7.4. Please refer to vial label for lot-specific concentration.
• Unit Definition: One unit is defined as the amount of protein that when reconstituted with Cdk5 will transfer 1 pmol of phosphate to Histone H1 peptide (9-18) per min at 30°C, pH 7.2.
• Specific Activity: ≥100,000 units/mg protein.
• Toxicity: Standard Handling (MSDS available upon request).
• Storage: -20°C . Avoid freeze/thaw Following initial thaw, aliquot and freeze (-20°C).

Gene Information

• Gene Name: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [ Bos taurus ]
• Synonyms:
  cyclin-dependent kinase 5, regulatory subunit 1 (p35); P25/P35; cyclin-dependent kinase 5 activator 1; p23; CDK5 activator 1; TPKII regulatory subunit; tau protein kinase II 23 kDa subunit; cyclin-dependent kinase 5 regulatory subunit 1
• Gene ID: 282173
• mRNA Refseq: NM_174512
• Protein Refseq: NP_776937
• UniProt ID: Q28199
• Chromosome Location: 19
• Pathway: Alzheimer"s disease
• Function: cadherin binding; calcium ion binding; kinase activity; protein binding; cyclin-dependent protein kinase 5 activator activity; protein serine/threonine kinase activator activity