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Recombinant Human Mitogen-activated Protein Kinase 10, GST-His

Cat.No. : MAPK10-691H
Product Overview : Recombinant human JNK3 is fused at the N-terminus to a GST-His 6-thrombin cleavage site tag and expressed inS. frugiperda insect cellsusing a baculovirus expression system.
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  • Gene Information
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Cat. No. : MAPK10-691H
Description : The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis.
Source : S. frugiperda insect cells.
Form : Liquid.
Formulation : In 100 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol, pH 8.0.
Molar Mass : 82161 Da.
Specific Activity : ≥0.1 U/mg protein.
Unit Definition : One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Rb-CTF per min at 30 °C using variable concentrations of ATP (0.1-0.312 μM).
Purity : ≥90% by SDS-PAGE.
Storage : ≤ -70oC. Ship: Dry Ice Only.
Gene Name : MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens ]
Synonyms :
MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; p493F12; FLJ12099; FLJ33785; MGC50974; p54bSAPK; MAP kinase; OTTHUMP00000161180; OTTHUMP00000161183; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress activated protein kinase beta; EC 2.7.11.24; MAP kinase p49 3F12; OTTHUMP00000161182; c-Jun kinase 3
Gene ID : 5602
mRNA Refseq : NM_002753
Protein Refseq : NP_002744
MIM : 602897
UniProt ID : P53779
Chromosome Location : 4q22.1-q23
Pathway : Adipocytokine signaling pathway; Colorectal cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; GnRH signaling pathway; Insulin signaling pathway; MAPK signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; Wnt signaling pathway
Function : ATP binding; JUN kinase activity; MAP kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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