| Cat. No.: | MAPK1-918H |
| Product Overview: | Recombinant Human MAPK1 protein (Met 1-Ser 360), fused with the GST tag at the N-terminus, was expressed inInsect cells. |
| Description: | Mitogen-activated protein kinase 1, also known as Extracellular signal-regulated kinase 2, ERK-2, and MAPK1, is a member of the protein kinase superfamily and MAP kinase subfamily. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MKP-3 is a dual specificity phosphatase exclusively specific to MAPK1 for its substrate recognition and dephosphorylating activity. The activation of MAPK1 requires its phosphorylation by upstream kinases. |
| Source: | Insect cells. |
| Molecular Mass: | The recombinant human ERK2/GST chimera consists of 585 amino acids and predicts a molecular mass of 67 kDa as estimated in SDS-PAGE under reducing conditions. |
| Predicted N Terminal: | Met. |
| Purity: | > 98 % as determined by SDS-PAGE. |
| Formulation: | Lyophilized from sterile 50mM Tris , 100 mM Nacl, 0.5mM PMSF, 10%Glycerol, pH 8.0. |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Reconstitution: | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
| Storage And Stability: | Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Gene Name: | MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens ] |
| Synonyms: | MAPK1; mitogen-activated protein kinase 1; ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAP kinase 2; Mitogen-activated protein kinase 2; Extracellular signal-regulated kinase 2; OTTHUMP00000174492; MAP kinase 2; protein tyrosine kinase ERK2 |
| Gene ID: | 5594 |
| mRNA Refseq: | NM_002745 |
| Protein Refseq: | NP_002736 |
| MIM: | 176948 |
| UniProt ID: | P28482 |
| Chromosome Location: | 22q11.2; 22q11.21 |
| Pathway: | Acute myeloid leukemia; Adherens junction; Alzheimer"s disease; Axon guidance; cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Dorso-ventral axis formation; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway |
| Function: | ATP binding; MAP kinase 2 activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; phosphotyrosine binding; protein binding; protein serine/threonine kinase activity; transferase activity |
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