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Recombinant Human MAPK1, GST-tagged

Cat.No. : MAPK1-918H
Product Overview : Recombinant Human MAPK1 protein (Met 1-Ser 360), fused with the GST tag at the N-terminus, was expressed inInsect cells.
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Cat. No. : MAPK1-918H
Description : Mitogen-activated protein kinase 1, also known as Extracellular signal-regulated kinase 2, ERK-2, and MAPK1, is a member of the protein kinase superfamily and MAP kinase subfamily. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MKP-3 is a dual specificity phosphatase exclusively specific to MAPK1 for its substrate recognition and dephosphorylating activity. The activation of MAPK1 requires its phosphorylation by upstream kinases.
Source : Insect cells.
Molecular Mass : The recombinant human ERK2/GST chimera consists of 585 amino acids and predicts a molecular mass of 67 kDa as estimated in SDS-PAGE under reducing conditions.
Predicted N Terminal : Met.
Purity : > 98 % as determined by SDS-PAGE.
Formulation : Lyophilized from sterile 50mM Tris , 100 mM Nacl, 0.5mM PMSF, 10%Glycerol, pH 8.0.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Storage And Stability : Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens ]
Synonyms : MAPK1; mitogen-activated protein kinase 1; ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAP kinase 2; Mitogen-activated protein kinase 2; Extracellular signal-regulated kinase 2; OTTHUMP00000174492; MAP kinase 2; protein tyrosine kinase ERK2
Gene ID : 5594
mRNA Refseq : NM_002745
Protein Refseq : NP_002736
MIM : 176948
UniProt ID : P28482
Chromosome Location : 22q11.2; 22q11.21
Pathway : Acute myeloid leukemia; Adherens junction; Alzheimer"s disease; Axon guidance; cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Dorso-ventral axis formation; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway
Function : ATP binding; MAP kinase 2 activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; phosphotyrosine binding; protein binding; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MAPK1 be used as a biomarker for cancer diagnosis? 12/28/2021

MAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.

How can MAPK1 be targeted in drug development for non-cancer conditions? 11/03/2021

MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.

In what other clinical conditions is MAPK1 relevant? 01/12/2020

MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.

Are there targeted therapies that inhibit MAPK1 for cancer treatment? 10/27/2018

Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.

Can MAPK1 be used for personalized medicine approaches? 08/19/2017

Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.

Customer Reviews (3)

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Reviews
03/24/2022

    Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

    03/26/2021

      In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.

      03/11/2020

        The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

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