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Recombinant Human PTPN1, His tagged

Cat.No. : PTPN1-764H
Product Overview : Recombinant Human PTPN1 (NP_002818.1) (Glu 2 -Asn 321), fused with a polyhistide tag at the N-terminus, was produced in E. coli.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His
Form : Lyophilized from sterile 10mM HEPES, 500mM NaCl, 1mM DTT, 1mM EDTA, pH 7.5
Molecular Mass : The recombinant human PTPN1consisting of 327 amino acids and has a calculated molecular mass of 38 kDa. It migrates as an approximately 36 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : PTPN1 protein tyrosine phosphatase, non-receptor type 1 [ Homo sapiens ]
Official Symbol : PTPN1
Gene ID : 5770
mRNA Refseq : NM_002827
Protein Refseq : NP_002818
MIM : 176885
UniProt ID : P18031

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of altered PTPN1 activity on obesity and related metabolic disorders? 10/12/2022

Altered PTPN1 activity is associated with obesity, as it impacts pathways involved in energy balance and fat storage.

How do genetic variations in PTPN1 contribute to metabolic disease susceptibility? 05/03/2020

Genetic variations in PTPN1 can affect its activity and thereby influence metabolic processes and disease risk.

What role does PTPN1 play in the development of insulin resistance and type 2 diabetes? 04/14/2020

PTPN1 is implicated in insulin resistance, potentially contributing to the development of type 2 diabetes.

How does PTPN1 regulate insulin signaling and glucose metabolism? 12/21/2018

It negatively regulates insulin signaling by dephosphorylating insulin receptor substrates, affecting glucose uptake and metabolism.

How does PTPN1 interact with other signaling molecules in regulating metabolic pathways? 02/15/2018

PTPN1 interacts with various signaling proteins, playing a role in diverse metabolic pathways including lipid and glucose metabolism.

What is the primary function of PTPN1 in cellular signaling? 04/04/2017

PTPN1, also known as Protein Tyrosine Phosphatase Non-Receptor Type 1, is key in dephosphorylating proteins involved in signal transduction.

What potential therapeutic applications could arise from targeting PTPN1 in metabolic diseases? 04/03/2017

Targeting PTPN1 could offer therapeutic benefits in treating insulin resistance, type 2 diabetes, and obesity.

Customer Reviews (3)

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Reviews
04/06/2023

    Timely and precise. Essential for achieving research goals.

    08/30/2020

      Efficient service, valuable insights. Key to research success.

      03/26/2018

        Saves time and resources. Critical for our research.

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