Recombinant Human CDKN2C, T7-tagged


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Recombinant Human CDKN2C, T7-tagged

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Cat. No. : CDKN2C-3049H
Product Overview : Recombinant Human CDKN2C was produced inE.coliwith a T7 tag at N-terminus. MW = 18127 Da (1-168 aa).
Description : Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Source : E.coli.
Form : 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.
Purity : 95%.
Applications : MS. SDS.
PDB rendering based on 1bu9. :

Gene Name : CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [ Homo sapiens ]
Synonyms : CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18; INK4C; p18-INK4C; cyclin-dependent kinase inhibitor 2C; CDK6 inhibitor p18; OTTHUMP00000009731; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor p18; CDKN6; OTTHUMP00000009730; OTTHUMP00000046546; p18-INK4c; p18-INK6; Cyclin-dependent kinase 6 inhibitor
Gene ID : 1031
mRNA Refseq : NM_001262
Protein Refseq : NP_001253
MIM : 603369
UniProt ID : P42773
Chromosome Location : 1p32
Pathway : Cell cycle
Function : cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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