Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged BIRC2-3104H

Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged


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Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged

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Cat. No. : BIRC2-3104H
Product Overview : Recombinant Human BIRC2 (Glu 144-Leu 356) with a AVI tag at C-terminus and additonal two amino acids (Gly & Pro) at the N-terminus, was expressed in E.coli.
Description : Baculoviral IAP repeat-containing protein 2, also known as Inhibitor of apoptosis protein 2, HIAP2, c-IAP1, RING finger protein 48, and BIRC2, is a member of the IAP family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. The UBA (ubiquitin-associated) domain of IAPs is located between the BIR (baculovirus IAP repeat) domains and the CARD (caspase activation and recruitment domain) or the RING (really interesting new gene) domain of c-IAP1 and c-IAP2 or XIAP (X-linked IAP) respectively. c-IAP1 contains three BIR repeats, one CARD domain and one RING-type zinc finger. c-IAP1 and c-IAP2 are recruited to tumor necrosis factor receptor 1 (TNFR1) associated complexes where they can regulate receptor-mediated signaling. Both c-IAP1 and c-IAP2 have been implicated in TNFalpha-stimulated NF-kappaB activation. Treatment of cells with IAP antagonists leads to proteasomal degradation of c-IAP1 and c-IAP2. Deletion or mutation of the UBA domain decreases this degradation, probably by diminishing the interaction of the c-IAPs with the proteasome. Ubiquitin binding may be an important mechanism for rapid turnover of auto-ubiquitinated c-IAP1 and c-IAP2.
Formulation : Lyophilized from sterile 10mM Tris, 5% glycerol, 0.5mM EDTA, 5mM DTT, pH 7.5
Purity : > 92 % as determined by SDS-PAGE
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Bio-activity : Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP.
Stability : Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal : Gly
Molecular Mass : The recombinant human cIAP1 ( Glu 144-Leu 356 ) consists of 230 amino acids and has a calculated molecular mass of 26.5 kDa as estimated by SDS-PAGE under reducing conditions.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : BIRC2 baculoviral IAP repeat-containing 2 [ Homo sapiens ]
Synonyms : BIRC2; baculoviral IAP repeat-containing 2; IAP homolog B; IAP-2; NFR2-TRAF signalling complex protein; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2; apoptosis inhibitor 1; baculoviral IAP repeat-containing protein 2; inhibitor of apoptosis protein 2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
Gene ID : 329
mRNA Refseq : NM_001166
Protein Refseq : NP_001157
MIM : 601712
UniProt ID : Q13490
Chromosome Location : 11q22
Pathway : Apoptosis; Focal adhesion; NOD-like receptor signaling pathway;Pathways in cancer; Small cell lung cancer; Ubiquitin mediated proteolysis; Apoptosis
Function : metal ion binding; protein N-terminus binding; protein binding; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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