"ADIPOQ" Related Products

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Recombinant Human ADIPOQ, His-tagged

Cat. No.: ADIPOQ-199H
Product Overview: Recombinant adiponectin produced inInsect cellsis a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions.
Description: Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages).
Source: Insect cells.
Purity: Greater than 97% (determined by SDS-PAGE and HPLC analysis).
Endotoxin Level: < 0.1 ng per μg of rHu Acrp30 (1EU/μg).
Biological Activity: Determined by a cytotoxic assay using M1 cells. The ED50for this effect is 3.0-6.0 μg/ml.
Form: Lyophilized from a sterile-filtered solution with no additives.
Reconstitution: Please Note: Always centrifuge product before opening vial. The lyophilized protein should be reconstituted with distilled, sterile water to a concentration of 0.1-1.0 mg/ml. For further dilution, carrier protein (0.1% BSA or HSA) should be added to avoid loss of bioactivity.
Storage: The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
Gene Name: ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens ]
Synonyms: ADIPOQ; adiponectin, C1Q and collagen domain containing; ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1; adiponectin; AdipoQ; apM1; adipose most abundant gene transcript 1; Adiponectin; Adipocyte, C1q and collagen domain-containing protein; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; Adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein
Gene ID: 9370
mRNA Refseq: NM_004797
Protein Refseq: NP_004788
MIM: 605441
UniProt ID: Q15848
Chromosome Location: 3q27
Pathway: Adipocytokine signaling pathway; PPAR signaling pathway; Type II diabetes melitus
Function: cytokine activity; eukaryotic cell surface binding; hormone activity; protein homodimerization activity

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