"NTRK1" Related Products

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Recombinant Human NTRK1, GST-His

Cat. No.: NTRK1-717H
Product Overview: Recombinant Human NTRK1, C-terminal fragment, amino acids G443-G796, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9insect cells.MW = 69,726 Da.
Description: TrkA is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor, or "NGF". As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival.
Source: Baculovirus infected Sf9 cells.
Purification: One-step affinity purification using GSH-agarose.
Product Identity: TRK-A was confirmed as TRK-A by by mass spectroscopy LC-ESIMS/MS (Protagen AG, Germany).
Storage Buffer: 50 mM HEPES-NaOH, pH 7.5; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Concentration: 0.133 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity: 29 pmol/μg×min.
Storage: -80°C. Avoid repeated freeze-thaw cycles!
Gene Name: NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ]
Synonyms: NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; p140-TrkA; DKFZp781I14186; Trk-A; Oncogene TRK; tyrosine kinase receptor A; high affinity nerve growth factor receptor; EC 2.7.10.1
Gene ID: 4914
mRNA Refseq: NM_001007792
Protein Refseq: NP_001007793
MIM: 191315
UniProt ID: P04629
Chromosome Location: 1q21-q22
Pathway: Apoptosis; Endocytosis; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer; Signalling by NGF
Function: ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity

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