"NTRK2" Related Products

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Recombinant Human NTRK2, GST-His

Cat. No. : NTRK2-718H
Product Overview : Recombinant Human TRK-B, C-terminal fragment, amino acids V526-G838, activated, N-terminal GST-HIS6 fusion protein with a Thrombin and 3C cleavage site, expressed inSf9insect cells.MW = 66,818 Da.
Description : TrkB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), NT-4 (neurotrophin-4), and NT-3 (neurotrophin-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival.
Source : Baculovirus infected Sf9 cells.
Purification : GST-Affinity Chromatography.
Product Identity : TRK-B was confirmed as TRK-B by mass spectroscopy LC-ESI-MS/MS.
Activation : in vitro auto-activation.
Storage Buffer : 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol.
Concentration : 0.133 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity : 140 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
Gene Name : NTRK2 neurotrophic tyrosine kinase, receptor, type 2 [ Homo sapiens ]
Synonyms : NTRK2; neurotrophic tyrosine kinase, receptor, type 2; TRKB; GP145-TrkB; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; tyrosine kinase receptor B; BDNF/NT-3 growth factors receptor; EC 2.7.10.1
Gene ID : 4915
mRNA Refseq : NM_001007097
Protein Refseq : NP_001007098
MIM : 600456
UniProt ID : Q16620
Chromosome Location : 9q22.1
Pathway : MAPK signaling pathway; Neurotrophin signaling pathway; Signalling by NGF
Function : ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity

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