Recombinant Human Mitogen-activated Protein Kinase 13

• Cat.No.: MAPK13-737H
• Product Overview: Recombinant Human p38-delta, full length, amino acids M1-L365, activated, untagged, was expressed inE.coli.MW = 42,430 Da.

Specification

• Cat. No.: MAPK13-737H
• Description: P38δ (SAPK4) is a member of the p38 MAPK family and is activated by chemical and environmental stresses as well as by proinflammatory cytokines. P38δ has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.
• Source: E.coli.
• Purification: GST-Affinity Chromatography.
• Activation: with MKK6-S207D/T211D.
• Product Identity: p38-delta was confirmed as p38-delta by mass spectroscopy LCESI-MS/MS.
• Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 20% glycerol.
• Concentration: 0.468 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
• Specific Activity: 481 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!

Gene Information

• Gene Name: MAPK13 mitogen-activated protein kinase 13 [ Homo sapiens ]
• Synonyms: MAPK13; mitogen-activated protein kinase 13; SAPK4; PRKM13; MGC99536; p38delta; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; mitogen activated protein kinase 13; EC 2.7.11.24
• Gene ID: 5603
• mRNA Refseq: NM_002754
• Protein Refseq: NP_002745
• MIM: 602899
• UniProt ID: O15264
• Chromosome Location: 6p21.31
• Pathway: Amyotrophic lateral sclerosis (ALS); Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; GnRH signaling pathway; Leukocyte transendothelial migration; MAPK signaling pathway; Neurotrophin signaling pathway; RIG-I-like receptor signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; VEGF signaling pathway; Signalling by NGF
• Function: ATP binding; MAP kinase activity; MAP kinase kinase activity; MP kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; transferase activity