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Recombinant Human FASLG, His-tagged

Cat. No.: FASLG-2703H
Product Overview: Recombinant human soluble Fas Ligand is a protein (156 amino acid residues) with a N-teminal His-Tag. It is expressed inCHO cells.
Description: Fas ligand (FasL) is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation. FasL is regarded as a potential target for immunotherapy.
Source: CHO cells.
Purity: Greater than 95% (determined by SDS-PAGE and HPLC analysis).
MW: 19.9 kDa.
Endotoxin Level: < 0.1 ng per μg (1EU/μg) of rHu sFasL.
Biological Activity: Determined by it"s ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. The ED50for this effect is < 10.0 ng/ml, corresponding to a specific activity of > 1 x 105units/mg.
Formulation: Lyophilized from a sterile-filtered solution with no additives.
Reconstitution: Please Note: Always centrifuge product briefly before opening the vial. Reconstitute in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage: The lyophilized powder, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted sFasL should be used immediately or stored in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.
Gene Name: FASLG Fas ligand (TNF superfamily, member 6) [ Homo sapiens ]
Synonyms:
FASLG; Fas ligand (TNF superfamily, member 6); FASL; CD178; CD95L; TNFSF6; APT1LG1; fas ligand; CD95 ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; CD95L protein; APTL; CD_antigen; Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form
Gene ID: 356
mRNA Refseq: NM_000639
Protein Refseq: NP_000630
MIM: 134638
UniProt ID: P48023
Chromosome Location: 1q23
Pathway: Allograft rejection; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Pathways in cancer; Type I diabetes mellitus
Function: cytokine activity; tumor necrosis factor receptor binding

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