Recombinant Rat Notch1, Fc Chimera

• Cat.No.: Notch1-2540R
• Product Overview: Recombinant Rat Notch1 produced inMouse NSO cellswas fused to Fc region of human.

Specification

• Cat. No.: Notch1-2540R
• Description: Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. A deficiency can be associated with bicuspid aortic valve.
• Source: Mammalian cells
• Molecular Weight: Calculated mol wt ~76 kDa; mol wt ~117 kDa by SDS-PAGE (reducing).
• Purity: ≥90% (SDS-PAGE).
• Form: Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
• Analysis Note: The biological activity is measured by its ability to bind Jagged-1.
• Storage: −20°C.

Gene Information

• Gene Name: Notch1 Notch homolog 1, translocation-associated (Drosophila) [ Rattus norvegicus ]
• Synonyms: Notch1; Notch homolog 1, translocation-associated (Drosophila); TAN1; NOTCH; neurogenic locus notch homolog protein 1; notch 1; Notch gene homolog 1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
• Gene ID: 25496
• mRNA Refseq: NM_001105721
• Protein Refseq: NP_001099191
• UniProt ID: Q07008
• Chromosome Location: 3p13
• Pathway: Dorso-ventral axis formation; Notch signaling pathway; Prion diseases
• Function: calcium ion binding; chromatin DNA binding; protein binding; receptor activity; sequence-specific DNA binding; transcription activator activity; transcription factor activity