||Recombinant Rat Notch1 produced inMouse NSO cellswas fused to Fc region of human.
||Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. A deficiency can be associated with bicuspid aortic valve.
||Mouse NSO cells.
||Calculated mol wt ~76 kDa; mol wt ~117 kDa by SDS-PAGE (reducing).
||Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
||The biological activity is measured by its ability to bind Jagged-1.