Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Murine Icos Ligand, Fc Chimera

Cat.No. : Icosl-2166M
Product Overview : Recombinant Murine Icos Ligand is produced in mammalian cells andfused with fused with human IgG1Fc. B7H2 extracellular domain (C-terminus fused with human IgG1 Fc) contains 457amino acids with predicted MW 51.21D x 2 (dimmer), and 12 cysteines (Fc has 6). It also has 6 N-link glycosylation sites with MW increase up to 30 kDa. It is ligand for the T-cell specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and differentiation. It induces also B-cell proliferation and differentiation in plasma cells.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : Icosl-2166M
Description : Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein.
Source : Mammalian cells.
Purity : >90%.
Quantity : 2.0mg/2ml PBS.
Availability : Back order, one month for production.
Storage : -70°C
Gene Name : Icosl icos ligand [ Mus musculus ]
Synonyms : Icosl; icos ligand; B7-H2; B7h; B7RP-1; GL50; GL50-B; ICOS-L; LICOS
Gene ID : 50723
mRNA Refseq : NM_015790
Protein Refseq : NP_056605
UniProt ID : Q9JHJ8
Chromosome Location : 10 C1
Pathway : Cell adhesion molecules (CAMs)
Function : protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All Icosl Products

Required fields are marked with *

My Review for All Icosl Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends