"UBA7" Related Products

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Recombinant Human UBA7, His-tagged

Cat. No.: UBA7-629H
Product Overview: Recombinant Human UBA7 isproduced inE. coliand fused at the C-terminus to a His-tag.
Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Source: E. coli.
Purity: >95%. Purified by Ni-affinity chromatography.
Application: Activation of ISG15 for ISGylation of specific proteins in presence of dedicated E2 conjugating/E3 ligase enzymes. ISGylation pathway studies. Test proteins for ISG15 E3 ligase activity. Test proteins as potential targets for ISG15 modification.
Storage: -80°C.
Gene Name: UBA7 ubiquitin-like modifier activating enzyme 7 [ Homo sapiens ]
Synonyms: UBA7; ubiquitin-like modifier activating enzyme 7; UBA1, ubiquitin-activating enzyme E1 homolog B; UBA7, ubiquitin-activating enzyme E1; ubiquitin-activating enzyme 7; ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1-like; ubiquitin-activating enzyme E1-related protein; ubiquitin-activating enzyme-2; ubiquitin-like modifier-activating enzyme 7; D8; UBE2; UBA1B; UBE1L; MGC12713
Gene ID: 7318
mRNA Refseq: NM_003335
Protein Refseq: NP_003326
MIM: 191325
UniProt ID: P41226
Chromosome Location: 3p21
Pathway: Parkinson"s disease; Ubiquitin mediated proteolysis
Function: ATP binding; ISG15 activating enzyme activity; ligase activity; nucleotide binding

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