"RAB27A" Related Products

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Recombinant Human RAB27A, His-tagged

Cat. No.: RAB27A-2479H
Product Overview: Recombinant human RAB27A, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 27 kDa (241aa).
Description: Ras-related protein Rab-27A, also known as RAB27A, belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Also, RAB27A regulates the cytotoxic granule exocytosis and affect T-lymphocyte and macrophage-activation. It is widely expressed with significant expression in pancreatic islets and pituitary tissue, and low expression in brain. Defects in RAB27A cause Griscelli syndrome type 2 (GS2).
Source: E.coli.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol.
Purity: > 90% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: RAB27A RAB27A, member RAS oncogene family [ Homo sapiens ]
Synonyms: RAB27A, member RAS oncogene family; GS2; RAM; RAB27; HsT18676; MGC117246; RAB27A; ras-related protein Rab-27A; rab-27; GTP-binding protein Ram;Ras-related protein Rab-27A; Rab-27
Gene ID: 5873
mRNA Refseq: NM_004580
Protein Refseq: NP_004571
MIM: 603868
UniProt ID: P51159
Chromosome Location: 15q15-q21.1
Pathway: Diabetes pathways
Function: GTP binding; GTPase activity; myosin V binding; nucleotide binding; protein binding

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