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GMP Recombinant Human FGF7 protein

Cat.No. : FGF7-142HG
Product Overview : Recombinant Human FGF7 protein was expressed in Escherichia coli. This product is produced under cGMP guidelines.
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Description : Human KGF-1 also known as Fibroblast growth factor 7 (FGF-7), is encoded by the FGF7 gene. KGF-1 only binds to the b splice form of the tyrosine kinase receptor, FGFR2b/KGFR. Affinity between KGF-1 and its receptor can be increased by heparin or heparan sulfate proteoglycan. FGF-10, also called keratinocyte growth factor 2 (KGF-2), shares 51 % amino acid sequence identity and similar function to KGF-1, but uses an additional receptor, FGFR2c. KGF-1 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. KGF-1 actives on keratinocytes, and exhibits mitogenic activity for epidermal cells, but essentially no activity for fibroblasts. KGF-1 has species crossactive, human KGF-1 shares 96 % amino acid sequence identity with murine, and 92 % with rat.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered solution in 20mM PB, pH 7.4, 500 mM NaCl, 0.02 % Tween-20.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 10⁵ IU/mg.
Molecular Mass : Approximately 18.9 kDa, a single, non-glycosylated polypeptide chain containing 163 amino acids.
Protein length : 163
AA Sequence : CNDMTPEQMATNVNCSSPERHTRSY DYMEGGDIRVRRLFCRTQWYLRIDK RGKVKGTQEMKNNYNIMEIRTVAVG IVAIKGVESEFYLAMNKEGKLYAKK ECNEDCNFKELILENHYNTYASAKW THNGGEMFVALNQKGIPVRGKKTKK EQKTAHFLPMAIT
Endotoxin : Less than 0.01 EU/µg of rHuKGF-1/FGF-7 GMP as determined by LAL method.
Purity : >98% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Tag : Non
Gene Name : FGF7
Official Symbol : FGF7
Synonyms : FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7;
Gene ID : 2252
mRNA Refseq : NM_002009
Protein Refseq : NP_002000
MIM : 148180
UniProt ID : P21781

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
03/21/2022

    I highly recommend the FGF7 Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

    05/01/2021

      The FGF7 Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.

      10/01/2017

        What truly distinguishes the FGF7 Protein is the unparalleled technical support provided by the manufacturer.

        Q&As (5)

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        How does FGF7 aid in tissue repair? 11/12/2022

        FGF7 stimulates the proliferation and migration of epithelial cells, which are crucial for repairing damaged tissues.

        Are there any side effects associated with FGF7 treatment? 05/09/2019

        Side effects are generally mild, such as local irritation at the site of application, but comprehensive studies are ongoing.

        Can FGF7 be used in regenerative medicine? 06/16/2018

        Yes, FGF7 is being explored for its potential in regenerating tissues and promoting healing in various medical fields.

        How is FGF7 administered in clinical settings? 08/01/2017

        FGF7 can be administered topically or via injection, depending on the specific condition being treated.

        Is FGF7 used in dermatology? 02/13/2016

        Yes, FGF7 has been investigated for its potential in treating skin disorders, including conditions like psoriasis and atopic dermatitis.

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