GMP Recombinant Human FGF7 protein
Cat.No. : | FGF7-142HG |
Product Overview : | Recombinant Human FGF7 protein was expressed in Escherichia coli. This product is produced under cGMP guidelines. |
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Description : | Human KGF-1 also known as Fibroblast growth factor 7 (FGF-7), is encoded by the FGF7 gene. KGF-1 only binds to the b splice form of the tyrosine kinase receptor, FGFR2b/KGFR. Affinity between KGF-1 and its receptor can be increased by heparin or heparan sulfate proteoglycan. FGF-10, also called keratinocyte growth factor 2 (KGF-2), shares 51 % amino acid sequence identity and similar function to KGF-1, but uses an additional receptor, FGFR2c. KGF-1 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. KGF-1 actives on keratinocytes, and exhibits mitogenic activity for epidermal cells, but essentially no activity for fibroblasts. KGF-1 has species crossactive, human KGF-1 shares 96 % amino acid sequence identity with murine, and 92 % with rat. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered solution in 20mM PB, pH 7.4, 500 mM NaCl, 0.02 % Tween-20. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 10⁵ IU/mg. |
Molecular Mass : | Approximately 18.9 kDa, a single, non-glycosylated polypeptide chain containing 163 amino acids. |
Protein length : | 163 |
AA Sequence : | CNDMTPEQMATNVNCSSPERHTRSY DYMEGGDIRVRRLFCRTQWYLRIDK RGKVKGTQEMKNNYNIMEIRTVAVG IVAIKGVESEFYLAMNKEGKLYAKK ECNEDCNFKELILENHYNTYASAKW THNGGEMFVALNQKGIPVRGKKTKK EQKTAHFLPMAIT |
Endotoxin : | Less than 0.01 EU/µg of rHuKGF-1/FGF-7 GMP as determined by LAL method. |
Purity : | >98% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Tag : | Non |
Gene Name : | FGF7 |
Official Symbol : | FGF7 |
Synonyms : | FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7; |
Gene ID : | 2252 |
mRNA Refseq : | NM_002009 |
Protein Refseq : | NP_002000 |
MIM : | 148180 |
UniProt ID : | P21781 |
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◆ Lysates | ||
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewI highly recommend the FGF7 Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.
The FGF7 Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.
What truly distinguishes the FGF7 Protein is the unparalleled technical support provided by the manufacturer.
Q&As (5)
Ask a questionFGF7 stimulates the proliferation and migration of epithelial cells, which are crucial for repairing damaged tissues.
Side effects are generally mild, such as local irritation at the site of application, but comprehensive studies are ongoing.
Yes, FGF7 is being explored for its potential in regenerating tissues and promoting healing in various medical fields.
FGF7 can be administered topically or via injection, depending on the specific condition being treated.
Yes, FGF7 has been investigated for its potential in treating skin disorders, including conditions like psoriasis and atopic dermatitis.
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