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Active GMP Recombinant Human TGFB3 protein, Fc-tagged

Cat.No. : TGFB3-193HG
Product Overview : GMP Recombinant Human TGFB3 protein(NP_003230)(375 aa), fused with Fc Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines.
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Human
Tag : Fc
Bio-activity : ED50 is determined by the ability of TGF-β3, which can inhibit the proliferation ability of mouse IL-4 dependent mouse HT-2 cells, and its value is <=0.1 ng/ml.
Molecular Mass : Recombinant Human TGF-β3 contains 375 aa. It has a predicted MW of 42.1 kDa.
Protein length : DNA sequence encoding Human TGF-β3(CAA33024.1) was expressed with Fc tag at the C-terminal.
Endotoxin : <=0.01EU/ug
Purity : >=95% by SDS-PAGE and HPLC
Storage : The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : TGFB3 transforming growth factor, beta 3 [ Homo sapiens ]
Official Symbol : TGFB3
Synonyms : TGFB3; transforming growth factor, beta 3; transforming growth factor beta-3; TGF-beta-3; ARVD; TGF-beta3; FLJ16571;
Gene ID : 7043
mRNA Refseq : NM_003239
Protein Refseq : NP_003230
MIM : 190230
UniProt ID : P10600

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a treatment for TGFB3? 12/16/2019

Currently, researchers are exploring treatments that target TGFB3. Several drugs and antibodies have shown potential efficacy against TGFB3 and are being used in clinical trials for the treatment of the disease.

How does TGFB3 participate in cell proliferation? 08/27/2019

TGFB3 can regulate cell proliferation by activating multiple signaling pathways, such as the Smad signaling pathway and non-Smad signaling pathway. It can promote the progression of the cell cycle or inhibit cell proliferation, depending on the cell type and context.

What are the applications of TGFB3 protein in clinical diagnosis? 07/25/2019

TGFB3 protein can be used as a biomarker to assist the clinical diagnosis of a variety of diseases, such as congenital developmental abnormalities, inflammatory diseases and fibrotic diseases. Measuring TGFB3 protein levels can provide an indicator of early diagnosis and prognostic assessment of disease.

Are there any genetic diseases associated with TGFB3? 06/23/2019

Mutations in TGFB3 have been found to be associated with inherited connective tissue diseases such as Loeys-Dietz syndrome and Marfan syndrome.

Is TGFB3 potentially used to treat pulmonary fibrosis? 05/25/2019

In pulmonary fibrosis, the expression of TGFB3 is elevated and is involved in the development of pulmonary fibrosis. Due to its important role in the pathological process, inhibition of the TGFB3 signaling pathway may be a potential strategy for the treatment of pulmonary fibrosis.

How is TGFB3 related to the immune system? 04/13/2019

TGFB3 plays an important regulatory role in the immune system. It can influence the immune response through the proliferation, differentiation, and functional regulation of immune cells.

Customer Reviews (3)

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Reviews
12/08/2019

    Reproducibility is very good, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of reproducibility.

    10/13/2019

      Their recombinant proteins are very soluble and can be easily dissolved in various buffers.

      05/19/2019

        Catalytic activity of this protein is very high, which can greatly reduce the time and energy required for chemical reactions and has high economic value.

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