Human CXCL14, Biotin-tagged

• Cat.No.: CXCL14-101H
• Product Overview: It is a synthetic Protein with Biotin tag.

Specification

• Description: BRAK is a novel member of the CXC chemokine family. The function of BRAK in cells remains largely unknown. It was identified by translating expressed sequence tags (ESTs) derived from breast and kidney carcinoma libraries and was found to be expressed ubiquitously in RNA from normal tissue extracts but absent from a variety of established in vitro tumor cell lines.
• Species: Human
• Tag: Biotin
• Form: Lyophilized.
• AA Sequence: H2N-SKCKCSRK GPKIRYSDVK KLEMKPKYPH CEEKMVIITT KSVSRYRGQE HCLHPKLQST KRFIKWYNAW NEKRRVYEEK(LC-Biotin)g-OH
• Applications: Activity Assay
• Storage: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
• Reconstitution: Recommended reconstitution in sterile phosphate buffered saline which containsat least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.

Gene Information

• Gene Name: CXCL14 chemokine (C-X-C motif) ligand 14 [ Homo sapiens ]
• Official Symbol: CXCL14
• Synonyms: CXCL14; chemokine (C-X-C motif) ligand 14; SCYB14, small inducible cytokine subfamily B (Cys X Cys), member 14 (BRAK); C-X-C motif chemokine 14; BMAC; bolekine; BRAK; breast and kidney; Kec; KS1; MIP 2g; NJAC; MIP-2 gamma; chemokine BRAK; tumor-suppressing chemokine; small-inducible cytokine B14; CXC chemokine in breast and kidney; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); KEC; MIP2G; MIP-2g; SCYB14; MGC10687
• Gene ID: 9547
• mRNA Refseq: NM_004887
• Protein Refseq: NP_004878
• MIM: 604186
• UniProt ID: O95715
• Chromosome Location: 5q31
• Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Senescence and Autophagy, organism-specific biosystem
• Function: chemokine activity

Reviews

10/30/2022

CXCL14 has important application value in the field of drug research and development, and has achieved certain research results.

08/15/2022

Good solubility, can be dissolved in a variety of buffers.

03/06/2022

I'm very satisfied. The quality is good and the price is affordable.

Q&As

What is the relationship of CXCL14 protein to other genes or proteins?

CXCL14 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

What is the specific role of CXCL14 protein in tumors?

CXCL14 plays a dual role in tumors, on the one hand, it can inhibit the proliferation and metastasis of tumor cells, and on the other hand, it can promote the immune escape of tumor cells.

What are the types of mutations in CXCL14 protein?

The types of mutations in CXCL14 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

Could disease be treated by modulating CXCL14 protein levels?

There are currently no drugs that directly regulate the levels of CXCL14 protein, but some diseases associated with CXCL14 protein can be treated by regulating its expression or inhibiting its activity.

How are mutations in CXCL14 protein detected and analyzed?

Mutations in the CXCL14 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of CXCL14 protein?

Studying the regulatory mechanism of CXCL14 protein requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.