Native Human ANPEP protein

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Native Human ANPEP protein

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Cat.No. : ANPEP-621H
Product Overview : Human ANPEP (967 amino acids) native protein from human serum.
Description : Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
Source : Human
Species : Human
Form : Liquid
Bio-activity : > 500 mU/mg (L-Leu-pNA at 37°C, pH 7.2).
Molecular Mass : 110-130 kDa
Purity : > 90% by SDS-PAGE
Applications : Functional Study; SDS-PAGE
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : In 20 mM Tris-HCl, 500 mM NaCl, 1 mM CaCl2, pH 7.4
Figure :

15% SDS-PAGE Stained with Coomassie Blue

Gene Name : ANPEP alanyl (membrane) aminopeptidase [ Homo sapiens ]
Official Symbol : ANPEP
Synonyms : ANPEP; alanyl (membrane) aminopeptidase; CD13, PEPN; aminopeptidase N; aminopeptidase M; gp150; LAP1; microsomal aminopeptidase; p150; AP-M; AP-N; hAPN; alanyl aminopeptidase; myeloid plasma membrane glycoprotein CD13; APN; CD13; P150; PEPN; GP150;
Gene ID : 290
mRNA Refseq : NM_001150
Protein Refseq : NP_001141
MIM : 151530
UniProt ID : P15144

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