Native Human Thrombospondin 1

• Cat.No.: THBS1-31514TH
• Product Overview: Full length native Human Thrombospondin isolated from the supernatant of activated platelets

Specification

• Description: The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol and water.
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the thrombospondin family.Contains 3 EGF-like domains.Contains 1 TSP C-terminal (TSPC) domain.Contains 1 TSP N-terminal (TSPN) domain.Contains 3 TSP type-1 domains.Contains 8 TSP type-3 repeats.Contains 1 VWFC domain.
• Tag: Non
• Publication:
  Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway (2013)

Gene Information

• Gene Name: THBS1 thrombospondin 1 [ Homo sapiens ]
• Official Symbol: THBS1
• Synonyms: THBS1; thrombospondin 1; thrombospondin-1; THBS; THBS 1; thrombospondin 1p180; TSP; TSP 1; TSP1
• Gene ID: 7057
• mRNA Refseq: NM_003246
• Protein Refseq: NP_003237
• MIM: 188060
• Uniprot ID: P07996
• Chromosome Location: 15q15
• Pathway: Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem
• Function: calcium ion binding; collagen V binding; eukaryotic cell surface binding; fibrinogen binding; fibroblast growth factor 2 binding

Reviews

05/14/2022

Quality exceeded my expectations.

09/08/2021

Satisfied customer, will return.

11/21/2020

Very pure, excellent results.

Q&As

In which tissues or cell types is THBS1 predominantly expressed?

THBS1 is widely expressed but is upregulated in response to injury or in certain disease states.

How is THBS1 implicated in cancer progression?

It can either promote or inhibit cancer progression, depending on the context.

How does THBS1 contribute to cell-matrix interactions?

It binds to extracellular matrix components, influencing cell attachment and signaling.

What role does THBS1 play in angiogenesis?

THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.

What therapeutic strategies are being explored targeting THBS1?

Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.

What is the primary function of THBS1 in cellular processes?

THBS1 modulates cell adhesion, proliferation, and migration.

Are there known genetic variations in THBS1 associated with specific diseases?

Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.