Recombinant Bovine PRNP Protein
Cat.No. : | PRNP-290B |
Product Overview : | Recombinant Bovine PRNP(24-241 aa) was expressed in E. coli. |
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Description : | Prion Protein (PrP) is an abundant cellular protein in mammalian neural tissue. It is associated with mammalian prion diseases, e.g. transmissible spongiforme encephalophathies that include human Creutzfeld-Jakob disease, bovine spongiforme encephalopathy, sheep scrapie, cervid’s chronic wasting disease and various rodent prion diseases. In the disease process, PrP undergoes protein aggregation into disease specific PrPSc. |
Source : | E. coli |
Species : | Bovine |
Form : | Finally dialysed in pure water, shock frozen in liquid nitrogen at a protein concentration of 0.25 mg/ml. |
Molecular Mass : | 23163 kg/mol |
Protein length : | 24-241 aa |
AA Sequence : | GSKKRPKPGGGWNTGGSRYPGQGSP GGNRYPPQGGGGWGQPHGGGWGQPH GGGWGQPHGGGWGQPHGGGWGQPHG GGGWGQGGTHGQWNKPSKPKTNMKH VAGAAAAGAVVGGLGGYMLGSAMSR P LIHFGSDYEDRYYRENMHRYPNQVY YRPVDQYSNQNNFVHDCVNITVKEH TVTTTTKGENFTETDIKMMERVVEQ MCITQYQRESQAYYQRGA |
Purity : | > 95% by SDS-PAGE |
Applications : | Prion Protein is frequently used in analytical aggregation assays |
Notes : | Thawing: Gentle agitation at 37 centigrade until no ice is left. Keep on ice. Do not refreeze |
Storage : | Store at -80 centigrade |
Concentration : | 0.25 mg/ml |
Gene Name : | PRNP prion protein [ Bos taurus ] |
Official Symbol : | PRNP |
Synonyms : | PrP; AltPrP; prion protein precursor PrP; prion protein variant a; prion protein variant b |
Gene ID : | 281427 |
mRNA Refseq : | NM_001271625 |
Protein Refseq : | NP_001258554 |
UniProt ID : | F7VJQ2 |
Products Types
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PRNP-555C | Recombinant Cynomolgus Monkey PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
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◆ Lysates | ||
PRNP-001HCL | Recombinant Human PRNP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionRegulating the expression level of PRNP can influence the development of neurodegenerative diseases and the treatment effect. For example, certain drugs can inhibit the death of neurons and slow the progression of the disease by inhibiting the expression level of PRNP.
PRNP has some association with other biomarkers. For example, in Creutzkok disease, abnormal folding and aggregation of PRNP proteins can be used with biomarkers such as amyloid to assess the diagnosis and prognosis of the disease.
PRNP expression levels can be used to aid in diagnosing neurodegenerative diseases and assessing prognosis. For example, in Alzheimer's disease, detecting mutations in the PRNP gene can predict disease development and prognosis.
It can be used to aid in diagnosing neurological diseases and assessing prognosis by detecting mutations and expression levels of the PRNP gene. For example, in Creutzkok disease, detecting mutations in the PRNP gene can predict the diagnosis and prognosis of the disease.
The expression level of PRNP is associated with the occurrence and progression of neurodegenerative diseases. For example, in Alzheimer's disease and Parkinson's disease, PRNP expression levels can change and may contribute to the development of the disease.
Mutations or abnormal expression of PRNP may be associated with a variety of neurological disorders. For example, in Creutzkok disease, mutations in the PRNP gene lead to abnormal protein folding and aggregation, which in turn causes the disease. In addition, in diseases such as Alzheimer's disease and Parkinson's disease, PRNP expression levels may also change and promote the development of the disease.
Customer Reviews (3)
Write a reviewPRNP showed good solubility in Western blot and could be easily dissolved in various buffers.
The stability of PRNP was still very good under different environmental conditions, indicating its wide applicability and stability.
Using PRNP for experiments, I can perform experimental manipulations more easily without having to worry about the reproducibility of experimental results.
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