| Description : |
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. |
| Source : |
E. coli |
| Species : |
Cervid |
| Tag : |
His |
| Molecular Mass : |
~ 17.3 kDa, reducing conditions |
| AA Sequence : |
MGGGWGQGGTHSQWNKPSKPKTNMK HVAGAAAAGAVVGGLGGYMLGSAMS RPLIHFGNDYEDRYYRENMYRYPNQ VYYRPVDQYNNQNTFVHDCVNITVK QHTVTTTTKGENFTETDIKMMERVV EQMCITQYQRESQAYYQLEHHHHHH |
| Purity : |
> 90% by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.11 mg/mL |
| Storage Buffer : |
Supplied as a 0.2 μm filtered solution in PBS, pH 8.0 |
