Recombinant Bovine TGFB1 Protein (279-390 aa), His-tagged

• Cat.No.: TGFB1-829B
• Product Overview: Recombinant Bovine TGFB1 Protein (279-390 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone rodeling as it is a potent stimulator of osteoblastic bone formation, causing chotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
• Source: E. coli
• Species: Bovine
• Tag: His
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 16.8 kDa
• Protein length: 279-390 aa
• AA Sequence: ALDTNYCFSSTEKNCCVRQLYIDFR KDLGWKWIHEPKGYHANFCLGPCPY IWSLDTQYSKVLALYNQHNPGASAA PCCVPQALEPLPIVYYVGRKPKVEQ LSNMIVRSCKCS
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: TGFB1 transforming growth factor beta 1 [ Bos taurus (cattle) ]
• Official Symbol: TGFB1
• Gene ID: 282089
• mRNA Refseq: NM_001166068
• Protein Refseq: NP_001159540
• UniProt ID: P18341