| Species : |
Chicken |
| Source : |
Yeast |
| Tag : |
Non |
| Description : |
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. |
| Molecular Mass : |
The Chicken IL-6 recombinant protein has a predicted molecular weight of 22.0 kDa. |
| AA Sequence : |
VPLPAAADSS GEVGLEEEAG ARRALLDCEP LARVLRDRAV QLQDEMCKKF TVCENSMEML VRNNLNLPKV TEEDGCLLAG FDEEKCLTKL SSGLFAFQTY LEFIQETFDS EKQNVESLCY STKHLAATIR QMVINPDEVV IPDSAAQKSL LANLKSDKDW IEKITMHLIL RDFTSFMEKT VRAVRYLKKT RSFSA (195) |
| Applications : |
The Chicken IL-6 endotoxin-free recombinant protein can be used in cell culture, as an IL-6 ELISA Standard, and as a Western Blot Control. |
| Publications : |
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