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Recombinant Cynomolgus ALDH3A2 Protein, His-tagged

Cat.No. : ALDH3A2-293C
Product Overview : Recombinant Cynomolgus ALDH3A2 full length or partial length protein was expressed.
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  • Gene Information
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Source : Mammalian Cells
Species : Cynomolgus
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : ALDH3A2 aldehyde dehydrogenase 3 family, member A2 [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : ALDH3A2
Synonyms : ALDH3A2; Aldehyde dehydrogenase family 3 member A2;
Gene ID : 102138923
mRNA Refseq : NM_001283382
Protein Refseq : NP_001270311
MIM :
UniProt ID : Q60HH8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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Are there any drugs or treatments that target ALDH3A2? 02/26/2023

Currently, there are no specific drugs or treatments designed to target ALDH3A2 directly. However, certain therapeutic strategies are being explored to alleviate the symptoms of Sjögren-Larsson syndrome (SLS), which is caused by mutations in the ALDH3A2 gene. These include symptomatic management of ichthyosis with moisturizers and emollients to improve the skin condition, physical therapy for spasticity management, and potentially gene therapy approaches to correct the underlying genetic defect in affected individuals. The development of targeted treatments for ALDH3A2-related conditions is an area of active research.

Is ALDH3A2 expressed in other tissues besides the skin? 11/06/2022

Yes, ALDH3A2 is expressed in various tissues besides the skin, albeit at lower levels. It is found in the liver, brain, adipose tissue, and other organs. It is believed that ALDH3A2's enzyme activity in these tissues is involved in the metabolism of fatty aldehydes and in protecting cells against oxidative damage.

Can ALDH3A2 gene therapy potentially cure or treat Sjögren-Larsson syndrome? 08/30/2022

Gene therapy holds promise as a potential treatment for Sjögren-Larsson syndrome (SLS), which is caused by mutations in the ALDH3A2 gene. Preclinical studies using animal models have shown positive results, with gene replacement strategies effectively restoring ALDH3A2 activity and improving symptoms. However, the development of safe and effective gene therapy approaches for SLS is still in the early stages, and more research is needed before it can be considered a viable treatment option for SLS.

Can ALDH3A2 be used as a biomarker for any diseases or conditions? 08/20/2022

ALDH3A2 has not been widely established as a biomarker for specific diseases or conditions. However, ALDH enzymes, including ALDH3A2, have been implicated in certain cancers, such as breast cancer and hepatocellular carcinoma, where their dysregulation may contribute to tumor progression and drug resistance. Further studies are needed to evaluate the potential use of ALDH3A2 as a biomarker for these diseases or other conditions.

Is ALDH3A2 involved in any other biological processes? 09/10/2021

Besides its role in lipid metabolism and detoxification, ALDH3A2 has been implicated in other biological processes. Some studies have suggested a potential involvement of ALDH3A2 in cell proliferation, differentiation, and apoptosis. However, the exact mechanisms and significance of these observations are still under investigation. Further research is needed to fully understand the broader biological functions of ALDH3A2.

How is the ALDH3A2 protein regulated in the body? 07/15/2021

The regulation of ALDH3A2 protein expression and activity is not yet fully understood. However, studies have indicated that certain transcription factors, such as PPARα (peroxisome proliferator-activated receptor alpha) and AP-1 (activator protein 1), can influence ALDH3A2 gene expression. Additionally, oxidative stress and inflammatory signals have been shown to affect ALDH3A2 activity. Further research is needed to fully elucidate the regulatory mechanisms of ALDH3A2.

Are there any known interactions or partners of ALDH3A2 protein? 03/24/2021

ALDH3A2 has been found to interact with various proteins to form functional complexes. For instance, it has been shown to interact with several aldehyde dehydrogenases, such as ALDH1A1 and ALDH1A3. These interactions suggest potential cooperative roles in aldehyde metabolism. ALDH3A2 has also been observed to interact with proteins involved in lipid metabolism, oxidative stress response, and cellular detoxification pathways. Further research is needed to fully understand the interactome of ALDH3A2 and its significance in cellular processes.

Are there any known natural inhibitors or activators of ALDH3A2? 12/27/2019

The identification of specific natural inhibitors or activators of ALDH3A2 is still an area of ongoing research. However, certain compounds and substances have been found to modulate the activity or expression of ALDH enzymes in general, including ALDH3A2. For example, disulfiram, a drug mainly used in the treatment of alcoholism, has been shown to inhibit various ALDH isoforms, including ALDH3A1 and ALDH1A1. Additionally, certain dietary factors and environmental chemicals may influence ALDH activity. Further studies are needed to determine any specific natural compounds that directly modulate ALDH3A2 activity.

Are there any known treatments or therapies for Sjögren-Larsson syndrome? 09/23/2019

Currently, there is no cure for Sjögren-Larsson syndrome, and treatment focuses on managing the symptoms. Skin care to alleviate ichthyosis, physical and occupational therapies to address spasticity and motor difficulties, and educational support for intellectual disability are among the treatment approaches. Additionally, medications such as retinoids may be prescribed to improve skin symptoms in some cases. However, ongoing research aims to develop targeted therapies that can address the underlying cause of the disease by restoring ALDH3A2 function or reducing the accumulation of fatty aldehydes.

Is ALDH3A2 an enzyme or a structural protein? 04/21/2019

ALDH3A2 is primarily known as an enzyme. It belongs to the aldehyde dehydrogenase enzyme family, which catalyzes the oxidation of aldehydes to their corresponding acids. ALDH enzymes are widely involved in various metabolic pathways. However, like many enzymes, ALDH3A2 does have certain structural characteristics that are important for its function, including specific amino acid residues that contribute to its active site and enzymatic activity.

How is ALDH3A2 related to lipid metabolism? 07/16/2018

ALDH3A2 is essential for the normal metabolism of lipids, specifically fatty aldehydes. It catalyzes the conversion of fatty aldehydes into fatty acids, which are essential components of triglycerides, phospholipids, and other lipid molecules. Dysfunction of ALDH3A2 leads to the accumulation of fatty aldehydes, disrupting lipid metabolism and contributing to the pathogenesis of Sjögren-Larsson syndrome.

Can mutations in the ALDH3A2 gene lead to other conditions or diseases besides Sjögren-Larsson syndrome? 11/30/2017

While mutations in the ALDH3A2 gene are primarily associated with Sjögren-Larsson syndrome, there have been rare reports of individuals with ALDH3A2 mutations exhibiting symptoms that do not fit the classic SLS triad. These atypical presentations include cases with intellectual disability and spasticity but without ichthyosis. However, the exact implications of these variants and their association with other conditions are still being investigated.

What diseases are associated with mutations in the ALDH3A2 gene? 01/13/2017

Mutations in the ALDH3A2 gene are associated with a rare autosomal recessive disorder called Sjögren-Larsson syndrome (SLS). SLS is characterized by a triad of symptoms including ichthyosis (a scaly skin condition), intellectual disability, and spasticity (stiff, rigid muscles). These mutations result in a deficiency of ALDH3A2 enzyme activity and the subsequent accumulation of fatty aldehydes, leading to the development of SLS.

Customer Reviews (4)

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Reviews
02/01/2022

    The bands of proteins in Western Blotting experiments were very clear.

    03/04/2019

      Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

      10/06/2018

        Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.

        06/29/2018

          Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

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