Recombinant Cynomolgus CD3E & CD3G protein, Fc-tagged
Cat.No. : | CD3E&CD3G-221C |
Product Overview : | Recombinant Cynomolgus CD3E(Met1-Asp117) & CD3G(Met1-Thr113) protein was fused to Fc region of human IgG1 at the C-terminus and expressed in HEK293 cells. |
- Specification
- Gene Information
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Description : | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. |
Source : | HEK293 |
Species : | Cynomolgus |
Tag : | Human IgG1 Fc |
Predicted N Terminal : | Gln22 & Gln23 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant cynomolgus CD3E/CD3G consists of 663 (334+329) amino acids and has a calculated molecular mass of 74.9 (37.6+37.3) KDa. |
Protein length : | 663 |
Endotoxin : | <1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 centigrade to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | CD3E |
Official Symbol : | CD3E |
Synonyms : | IMD18; T3E; TCRE |
Gene ID : | 102133065 |
mRNA Refseq : | NM_001283615.1 |
Protein Refseq : | NP_001270544.1 |
UniProt ID : | Q95LI5 |
Products Types
◆ Recombinant Protein | ||
CD3E-142H | Recombinant Human CD3E Protein, His and Fc-tagged | +Inquiry |
CD3E-138C | Recombinant Cynomolgus Monkey CD3E Protein, His (Fc)-Avi-tagged | +Inquiry |
CD3E-143H | Recombinant Human CD3E Protein, Strep-tagged | +Inquiry |
CD3E-982R | Recombinant Rhesus CD3E Protein (Met1-Asp117), His-Fc-tagged | +Inquiry |
CD3E-30H | Recombinant Human CD3E Protein (198 AA), C-Fc-tagged | +Inquiry |
◆ Lysates | ||
CD3E-1602CCL | Recombinant Cynomolgus CD3E cell lysate | +Inquiry |
CD3E-1275HCL | Recombinant Human CD3E cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.
There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.
There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.
Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.
CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.
Customer Reviews (3)
Write a reviewManufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.
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