Active Recombinant Cynomolgus CYP2C19 Protein
Cat.No. : | CYP2C19-126C |
Product Overview : | Recombinant cynomolgus CYP2C19 protein and human CYP-reductase without tag were coexpressed in E. coli. |
- Specification
- Gene Information
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Description : | Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not respond adequately or develop treatment related adverse events. This variable response among patients is in part due to genotype variability of CYP2C19, the gene encoding the CYP450 (CYP2C19) isoenzyme responsible for PPIs metabolism. |
Source : | E. coli |
Species : | Cynomolgus |
Bio-activity : | Cytochrome c Reductase Activity: 154 nmol/min/mg protein P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase]) Activity: Tolbutamide 4-hydroxylase Linear with time up to: 30 min(Determined at 350 µM substrate, using a P450 concentration of 100 pmol/ml) Linear with P450 up to: 100 pmol/ml(Determined at 350 µM substrate, using an incubation time of 20 min) Vmax: 1.5 pmol/min/pmol CYP Km: 437 μM |
Usage : | For laboratory (research) purposes only |
Storage : | Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice. |
Concentration : | P450 Concentration: 2.2 nmol/ml Protein Concentration: 12.3 mg/ml Specific P450 Content: 179 pmol/mg protein |
Storage Buffer : | 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA |
Gene Name : | CYP2C19 cytochrome P450 family 2 subfamily C member 19 [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | CYP2C19 |
Synonyms : | CYP2C19; cytochrome P450 family 2 subfamily C member 19; CYP2C75; cytochrome P450 2C9-like; cytochrome P450 family 2 subfamily C member 19; cytochrome P450 2C75; cytochrome P450, family 2, subfamily C, polypeptide 19 |
Gene ID : | 102147103 |
mRNA Refseq : | NM_001283290 |
Protein Refseq : | NP_001270219 |
UniProt ID : | Q0HA19 |
Products Types
◆ Recombinant Protein | ||
CYP2C19-2726H | Recombinant Human CYP2C19 protein(251-320 aa), C-His-tagged | +Inquiry |
CYP2C19-75H | Active Recombinant Human CYP2C19 Protein | +Inquiry |
CYP2C19-2797H | Recombinant Human CYP2C19 Protein, His-tagged, OVA Conjugated | +Inquiry |
CYP2C19-33H | Active Recombinant Human CYP2C19 Protein | +Inquiry |
CYP2C19-2793H | Recombinant Human CYP2C19 protein, His&Myc-tagged | +Inquiry |
◆ Assay kits | ||
Kit-2125 | Cytochrome P450 2C19 Inhibitor Screening Kit | +Inquiry |
Kit-2124 | Cytochrome P450 2C19 Fluorometric Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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