Recombinant Cynomolgus CYP2C19 Protein


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Recombinant Cynomolgus CYP2C19 Protein

CYP2C19 Related Products

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Cat.No. : CYP2C19-126C
Product Overview : Recombinant cynomolgus CYP2C19 protein and human CYP-reductase without tag were coexpressed in E. coli.
Description : Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not respond adequately or develop treatment related adverse events. This variable response among patients is in part due to genotype variability of CYP2C19, the gene encoding the CYP450 (CYP2C19) isoenzyme responsible for PPIs metabolism.
Source : E. coli
Species : Cynomolgus
Bio-activity : Cytochrome c Reductase Activity: 154 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Tolbutamide 4-hydroxylase
Linear with time up to: 30 min(Determined at 350 µM substrate, using a P450 concentration of 100 pmol/ml)
Linear with P450 up to: 100 pmol/ml(Determined at 350 µM substrate, using an incubation time of 20 min)
Vmax: 1.5 pmol/min/pmol CYP
Km: 437 μM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 2.2 nmol/ml
Protein Concentration: 12.3 mg/ml
Specific P450 Content: 179 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP2C19 cytochrome P450 family 2 subfamily C member 19 [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : CYP2C19
Synonyms : CYP2C19; cytochrome P450 family 2 subfamily C member 19; CYP2C75; cytochrome P450 2C9-like; cytochrome P450 family 2 subfamily C member 19; cytochrome P450 2C75; cytochrome P450, family 2, subfamily C, polypeptide 19
Gene ID : 102147103
mRNA Refseq : NM_001283290
Protein Refseq : NP_001270219
UniProt ID : Q0HA19

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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